Results 101 to 110 of about 289,302 (355)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The effects of canonical Wnt signaling pathways on the CXCR4 expression of bone marrow derived mesenchymal stem cells

Linchuang shenzangbing zazhi, 2017
Objective To evaluate the effects of Wnt signaling pathways on the CXCR4 expression of bone marrow mesenchymal stem cells(BMSCs),and to investigate the possible regulation mechanisms of the Wnt signaling pathways on the migration ability of BMSCs.Methods
SUN Ji-ping, MA Ying, ZHANG Wen-jing, LV Jia, YIN Ai-ping   +4 more
doaj  

Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. [PDF]

, 2018
The tumor promoter 12-O-tetra-decanoylphorbol-13-acetate (TPA) has been defined by its ability to promote tumorigenesis on carcinogen-initiated mouse skin.
Carson, Dennis A, Li, Shiyue, Liu, Shan-Shan, Lu, Desheng, Song, Jiaxing, Su, Zijie, Sun, Qi, Wang, Zhongyuan, Wei, Lei, Xia, Yuqing, Yu, Shubin, Zhao, Liang, Zhou, Liang   +12 more
core  

TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis [PDF]

, 2015
Truncating mutations in the tumor suppressor gene adenomatous polyposis coli (APC) are the initiating step in the vast majority of sporadic colorectal cancers, and they underlie familial adenomatous polyposis (FAP) syndromes.
Creytens, David, Geurs, Sarah, Naert, Thomas, Sanders, Ellen, Tran Thi, Hong, Van Imschoot, Griet, Van Nieuwenhuysen, Tom, Van Roy, Frans, Vleminckx, Kris   +8 more
core   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Anomalous vascularization in a Wnt medulloblastoma: A case report [PDF]

, 2016
BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature.
Cacchione, Antonella, Carai, Andrea, Colafati, Giovanna Stefania, Dell'Anna, Vito Andrea, Di Giannatale, Angela, Diomedi Camassei, Francesca, Ferretti, Elisabetta, Locatelli, Franco, Marrazzo, Antonio, Mastronuzzi, Angela, Miele, Evelina, Po, Agnese   +11 more
core   +2 more sources

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Tumor Suppressor miRNA-503 Inhibits Cell Invasion in Head and Neck Cancer through the Wnt Signaling Pathway via the WNT3A/MMP Molecular Axis [PDF]

, 2022
Shang-Ju Tang, Kang‐Hsing Fan, Guo-Rung You, Shiang‐Fu Huang, Chung‐Jan Kang, Yi‐Fang Huang, Yuchen Huang, Joseph Tung‐Chieh Chang, Ann‐Joy Cheng   +8 more
openalex   +1 more source

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma. [PDF]

, 2015
Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients.
Martinez-Barbera, JP
core   +1 more source