Results 51 to 60 of about 1,026,340 (233)
Cancer Biology & Therapy, 2018 Objective: To identify the significantly altered circRNAs and mRNAs in thyroid cancer, investigate their target miRNAs and determine their biological functions.
Fukun Chen +6 more
semanticscholar +1 more source
Promising Druggable Target in Head and Neck Squamous Cell Carcinoma: Wnt Signaling
Frontiers in Pharmacology, 2016 Canonical Wnt signaling pathway, also known as Wnt/β-catenin signaling pathway, is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration and differentiation.
Amnani Aminuddin, Pei Yuen Ng
doaj +1 more source
Role of microRNAs in regulation of WNT signaling pathway in urothelial and prostate cancers
Egyptian Journal of Medical Human Genetics, 2022 Background Urothelial cancer (UC) and prostate cancer (PCa) are the most common cancers among men with a high ratio of mortality in advanced-stages.
Mehdi Montazer +3 more
doaj +1 more source
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode [PDF]
, 2008 The inner ear derives from a patch of ectoderm defined by expression of the transcription factor Pax2. We recently showed that this Pax2^+ ectoderm gives rise not only to the otic placode but also to the surrounding cranial epidermis, and that Wnt ...
Groves, Andrew K. +3 more
core
The Casein Kinase I Family in Wnt Signaling [PDF]
, 2001 The canonical Wnt-signaling pathway is critical for many aspects of development, and mutations in components of the Wnt pathway are carcinogenic. Recently, sufficiency tests identified casein kinase Iϵ (CKIϵ) as a positive component of the canonical Wnt ...
Graff, Jonathan M. +2 more
core +1 more source
TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction
Frontiers in Cell and Developmental Biology, 2020 Wnt signaling pathway plays indispensable roles in embryonic development and adult tissue homeostasis. However, the regulatory mechanisms involved in Wnt ligand trafficking within and secretion from the signal sending cells is still relatively ...
Binbin Li, Lee A. Niswander
doaj +1 more source
Current Understanding on Role of the Wnt Signaling Pathway Effector TCF7L2 in Glucose Homeostasis.
Endocrine reviews, 2016 The role of the Wnt signaling pathway in metabolic homeostasis has drawn our intensive attention, especially after the genome-wide association study discovery that certain polymorphisms of its key effector TCF7L2 are strongly associated with the ...
T. Jin
semanticscholar +1 more source
Wnt/β-catenin signaling pathway in lung cancer
Medicine in Drug Discovery, 2022 The Wnt signaling pathway regulates cell proliferation, differentiation, migration, genetic stability, and apoptosis in almost all tissues and organs. It plays a crucial role in the normal development of embryos and the dynamic balance of adult tissues ...
Wenhua Zhu, Heng Wang, Di Zhu
doaj
Current Issues in Molecular Biology, 2023 Abnormal inactivation of the Wnt/β-catenin signaling pathway is involved in skin diseases like androgenetic alopecia, vitiligo and canities, but small-molecule activators are rarely described.
Jae Young Shin +4 more
doaj +1 more source
Cell-type specific potent Wnt signaling blockade by bispecific antibody. [PDF]
, 2018 Cell signaling pathways are often shared between normal and diseased cells. How to achieve cell type-specific, potent inhibition of signaling pathways is a major challenge with implications for therapeutic development.
Bidlingmaier, Scott +6 more
core +2 more sources