Results 51 to 60 of about 1,031,479 (367)
Wnt5a Signaling in Normal and Cancer Stem Cells. [PDF]
, 2017 Wnt5a is involved in activating several noncanonical Wnt signaling pathways, which can inhibit or activate canonical Wnt/β-catenin signaling pathway in a receptor context-dependent manner.
Kipps, Thomas J +2 more
core +2 more sources
The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators.
Annual Review of Biochemistry, 2022 The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regulate the ...
E. Y. Rim, H. Clevers, R. Nusse
semanticscholar +1 more source
WNT-mediated Modulation of Bone Metabolism: Implications for WNT Targeting to Treat Extraskeletal Disorders [PDF]
, 2017 The WNT-signaling pathway is involved in cellular and tissue functions that control such diverse processes as body axis patterning, cellular proliferation, differentiation, and life span.
Bullock, Whitney A. +1 more
core +1 more source
Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder
Translational Psychiatry, 2018 The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the function and structure of the adult nervous system.
E. Hoseth +13 more
semanticscholar +1 more source
Targeting the Wnt/β-catenin signaling pathway in cancer
Journal of Hematology & Oncology, 2020 The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response.
Ya Zhang, Xin Wang
semanticscholar +1 more source
Role of the Wnt signaling pathway in keratoacanthoma [PDF]
Cancer Reports, 2019 AbstractBackgroundKeratoacanthoma (KA) has a unique life cycle of rapid growth and spontaneous regression that shows similarities to the hair follicle cycle, which involves an active Wnt signaling during physiological regeneration. We analyzed the expression of the Wnt signaling proteins β‐catenin, Lef1, Sox9, and Cyclin D1 in young and old human KAs ...
Solveig Norheim Andersen +6 more
openaire +3 more sources
Wnt Signaling in Hepatocellular Carcinoma: Biological Mechanisms and Therapeutic Opportunities
CellsHepatocellular carcinoma (HCC), characterized by significant morbidity and mortality rates, poses a substantial threat to human health. The expression of ligands and receptors within the classical and non-classical Wnt signaling pathways plays an ...
Yingying Zhu, Yajing He, Runliang Gan
doaj +1 more source
Journal of experimental & clinical cancer research : CR, 2018 40–50% of colorectal cancer (CRC) patients develop metastatic disease; the presence of metastasis hinders the effective treatment of cancer through surgery, chemotherapy and radiotherapy, which makes 5-year survival rate extremely low; therefore ...
Mengmeng Zhang +14 more
semanticscholar +1 more source
Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]
, 2018 Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar +16 more
core +2 more sources
The Casein Kinase I Family in Wnt Signaling [PDF]
, 2001 The canonical Wnt-signaling pathway is critical for many aspects of development, and mutations in components of the Wnt pathway are carcinogenic. Recently, sufficiency tests identified casein kinase Iϵ (CKIϵ) as a positive component of the canonical Wnt ...
Graff, Jonathan M. +2 more
core +1 more source