Results 61 to 70 of about 1,031,479 (367)

Wnt-signaling pathway in pathogenesis of glioblastoma multiforme

Успехи молекулярной онкологии, 2019
The Wnt-signaling pathway regulates various biological processes, such as embryonic development, self-renewal, proliferation, differentiation and migration of stem cells.
Yu. D. Vasilets, N. E. Arnotskaya, I. A. Kudryavtsev, V. E. Shevchenko   +3 more
doaj   +1 more source

Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. [PDF]

PLoS ONE, 2015
WNT signaling is a complex process comprising multiple pathways: the canonical β-catenin-dependent pathway and several alternative non-canonical pathways that act in a β-catenin-independent manner.
Michaela Bayerlová, Florian Klemm, Frank Kramer, Tobias Pukrop, Tim Beißbarth, Annalen Bleckmann   +5 more
doaj   +1 more source

Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway

PLoS ONE, 2017
Glioblastoma multiforme (GBM) is a grade IV astrocytoma and the most common form of malignant brain tumor in adults. GBM remains one of the most fatal and least successfully treated solid tumors: current therapies provide a median survival of 12–15 ...
C. Cilibrasi, G. Riva, Gabriele Romano, M. Cadamuro, R. Bazzoni, V. Butta, Laura Paoletta, L. Dalprà, M. Strazzabosco, M. Lavitrano, R. Giovannoni, A. Bentivegna   +11 more
semanticscholar   +1 more source

TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction

Frontiers in Cell and Developmental Biology, 2020
Wnt signaling pathway plays indispensable roles in embryonic development and adult tissue homeostasis. However, the regulatory mechanisms involved in Wnt ligand trafficking within and secretion from the signal sending cells is still relatively ...
Binbin Li, Lee A. Niswander
doaj   +1 more source

Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral Sclerosis

Cells, 2021
The WNT signaling pathway plays an important role in the physiological and pathophysiological processes of the central nervous system and the neurodegenerative disease amyotrophic lateral sclerosis (ALS).
Xin Jiang, Yingjun Guan, Zhenhan Zhao, Fandi Meng, Xuemei Wang, Xueshuai Gao, Jinmeng Liu, Yanchun Chen, Fenghua Zhou, Shuanhu Zhou, Xin Wang   +10 more
doaj   +1 more source

Wnt signaling pathway in non-small cell lung cancer.

Journal of the National Cancer Institute, 2014
Wnt/β-catenin alterations are prominent in human malignancies. In non-small cell lung cancer (NSCLC), β-catenin and APC mutations are uncommon, but Wnt signaling is important in NSCLC cell lines, and Wnt inhibition reduces proliferation.
D. Stewart
semanticscholar   +1 more source

FMRP modulates the Wnt signalling pathway in glioblastoma

Cell Death & Disease, 2022
AbstractConverging evidence indicates that the Fragile X Messenger Ribonucleoprotein (FMRP), which absent or mutated in Fragile X Syndrome (FXS), plays a role in many types of cancers. However, while FMRP roles in brain development and function have been extensively studied, its involvement in the biology of brain tumors remains largely unexplored ...
Pedini G., Buccarelli M., Bianchi F., Pacini L., Cencelli G., D'Alessandris Q. G., Martini M., Giannetti S., Sasso F., Melocchi V., Farace M. G., Achsel T., Larocca L. M., Ricci-Vitiani L., Pallini R., Bagni C.   +15 more
openaire   +8 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode [PDF]

, 2008
The inner ear derives from a patch of ectoderm defined by expression of the transcription factor Pax2. We recently showed that this Pax2^+ ectoderm gives rise not only to the otic placode but also to the surrounding cranial epidermis, and that Wnt ...
Groves, Andrew K., Jayasena, Chathurani S., Ohyama, Takahiro, Segil, Neil   +3 more
core  

Making sense of Wnt signaling—linking hair cell regeneration to development [PDF]

, 2015
Wnt signaling is a highly conserved pathway crucial for development and homeostasis of multicellular organisms. Secreted Wnt ligands bind Frizzled receptors to regulate diverse processes such as axis patterning, cell division, and cell fate specification.
Alan G. Cheng, Grace S. Kim, Lina Jansson   +2 more
core   +2 more sources