Results 71 to 80 of about 22,945 (169)

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Role of NS1 and TLR3 in Pathogenesis and Immunity of WNV

Viruses, 2019
West Nile Virus (WNV) is a mosquito-transmitted flavivirus which causes encephalitis especially in elderly and immunocompromised individuals. Previous studies have suggested the protective role of the Toll-like receptor 3 (TLR3) pathway against WNV entry
Sameera Patel, Alessandro Sinigaglia, Luisa Barzon, Matteo Fassan, Florian Sparber, Salome LeibundGut-Landmann, Mathias Ackermann   +6 more
doaj   +1 more source

Dengue Seroprevalence Among Blood Donors in the Lazio Region (Italy): Is There an Iceberg Beneath the Surface?

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT During 2023, dengue virus (DENV) autochthonous circulation was detected in Lazio, Italy. To investigate the magnitude of the phenomenon, anti‐DENV serological status of blood donors residing in previously affected Rome municipalities was evaluated.
Martina Spaziante, Lugi Rosa, Francesca Colavita, Ilaria Mussetto, Gabriella De Carli, Valentina Vantaggio, Alessandro Agresta, Sabrina Coen, Silvia Cammisa, Alessandra D'Abramo, Gaetano Maffongelli, Stefania Vaglio, Stefano Iaboni, Ida Casorelli, Luca Mele, Luciana Teofili, Paola Scognamiglio, Andrea Siddu, Emanuele Nicastri, Fabrizio Maggi, Enrico Girardi, ARBODONORS Working Group, Deborah Ilaria Gadaleta, Diletta D'Epiro, Enrico Duranti, Manuela Cornacchia, Tecla Maria Fontana, Maria Laura Foddai, Francesca Frangiolini, Giuseppina Antonia Natale, Mafalda De Rienzo, Francesco Vairo   +31 more
wiley   +1 more source

Genomic characterization of a severe West Nile Virus transmission season using a single reaction amplicon sequencing approach.

PLoS Neglected Tropical Diseases
West Nile virus (WNV) is an endemic arthropod-borne virus that has routinely caused seasonal outbreaks in the United States since it was first detected in 1999.
Shawn Freed, Sarah Chandler, Sarah Uhm, Zach Pella, Dikchha Gurung, Hallie Smith, Tammy Dowdy, Amanda M Bartling, Ava Butz, Michael R Wiley, M Jana Broadhurst, Sydney Stein, Emily L McCutchen, Jeff Hamik, Peter C Iwen, Nick Downey, Kaylee S Herzog, Joseph R Fauver   +17 more
doaj   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Design and Synthesis of a Potent, Cell Active Purine‐Based Amidoxime Against the Dengue Virus

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
Scaffold hopping from our previous indolazepinone hit exemplifies purine SP‐835G with DENV2 EC50 0.1 µM, CC50>100 µM, clogP 3.61. Docking studies support its amidine metabolite operates as an allosteric inhibitor of DENV(pro). A flexible ether linker appears pivotal for enhancing binding and activity.
Dimitrios Kiousis, Despoina Giannioti, Georgia Kalyva, Vasiliki Zogali, Maharah Binte Abdul Mahid, Kitti Wing Ki Chan, Minos‐Timotheos Matsoukas, Subhash G. Vasudevan, Gerasimos Rassias   +8 more
wiley   +1 more source

Competition between Usutu virus and West Nile virus during simultaneous and sequential infection of Culex pipiens mosquitoes

Emerging Microbes and Infections, 2020
Usutu virus (USUV) and West Nile virus (WNV) are closely related mosquito-borne flaviviruses that are mainly transmitted between bird hosts by vector mosquitoes. Infections in humans are incidental but can cause severe disease.
Haidong Wang, Sandra R. Abbo, Tessa M. Visser, Marcel Westenberg, Corinne Geertsema, Jelke J. Fros, Constantianus J. M. Koenraadt, Gorben P. Pijlman   +7 more
doaj   +1 more source

Diagnosis of west Nile neuroinvasive disease in humans

Archives of Veterinary Medicine, 2018
West Nile virus (WNV) is arbovirus distributed all around the world. In humans, 80% of infection cases are asymptomatic. In 20% of infected people, a febrile self-limiting illness is reported. WNV has the potential for fatal neuroinvasive disease.
Ivana Hrnjaković Cvjetković, Vesna Milošević, Tamaš Petrović, Dušan Petrić, Gordana Kovačević, Jelena Radovanov, Aleksandra Patić, Nataša Nikolić, Sandra Stefan Mikić, Sofija Cvjetković, Dejan Cvjetković   +10 more
doaj   +1 more source

Nanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritin

International Journal of Nanomedicine
Michaela Vojnikova,1,2,* Martina Sukupova,1,3,* Michal Stefanik,1,4 Petra Strakova,3– 5 Jan Haviernik,4 Katerina Kapolkova,1 Eliska Gruberova,1 Klara Raskova,1 Hana Michalkova,1 Pavel Svec,1 Marie Peskova Kudlickova,1 Ivana Huvarova,4 Daniel ...
Vojnikova M, Sukupova M, Stefanik M, Strakova P, Haviernik J, Kapolkova K, Gruberova E, Raskova K, Michalkova H, Svec P, Kudlickova MP, Huvarova I, Ruzek D, Salat J, Pekarik V, Eyer L, Heger Z   +16 more
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