Results 71 to 80 of about 384 (136)

Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice

Journal of Diabetes Research, Volume 2025, Issue 1, 2025.
Background: Fat accumulation in the pancreas, known as nonalcoholic fatty pancreatic disease (NAFPD), is associated with obesity and may lead to prediabetes and Type 2 diabetes. Reducing endoplasmic reticulum stress and enhancing autophagy could offer therapeutic benefits. This study examines the effects of fisetin (FSN) and hydroxychloroquine (HCQ) on
Mahboobe Sattari, Amin Karimpour, Maryam Akhavan Taheri, Bagher Larijani, Reza Meshkani, Ozra Tabatabaei-Malazy, Ghodratollah Panahi, Janet Southerland   +7 more
wiley   +1 more source

Diabetes Insipidus as an Early Clinical Indicator of Wolfram Syndrome Type 1: Evidence From a Symptom‐Based Screening Approach

Pediatric Diabetes, Volume 2025, Issue 1, 2025.
Objective: Wolfram Syndrome Type 1 (WS1) is a rare neurodegenerative disorder characterized by diabetes insipidus (DI), diabetes mellitus (DM), optic atrophy (OA), and deafness (D) due to biallelic mutations in the WFS1 gene. As the cardinal symptoms of DI, polyuria and polydipsia, overlap with those of DM, DI might be underdiagnosed or delayed in the ...
Ozge Beyza Gundogdu Ogutlu, Atilla Cayır, Ayşe Sena Donmez, Serkan Bilge Koca, Oguzhan Yarali, Huseyin Demirbilek, Andrea Scaramuzza   +6 more
wiley   +1 more source

A Case of Wolfram Syndrome from South India: Diabetologist’s Perspective

International Journal of Diabetes and Technology
Wolfram syndrome (WS), also called diabetes insipidus, diabetes mellitus, optic atrophy, and deafness, is a rare autosomal-recessive genetic disorder that causes childhood-onset diabetes mellitus, diabetes insipidus, optic atrophy, and deafness as well ...
Shahana Yasmin, R. Sreelakshmi, Gopika Krishnan, Jothydev Kesavadev   +3 more
doaj   +1 more source

Topology of WFS1 Variants Linked With Islet Function and Higher Risk of Urological Symptoms in WFS1‐Associated Disease

Pediatric Diabetes, Volume 2025, Issue 1, 2025.
Wolfram syndrome type 1 gene (WFS1), which encodes a transmembrane (TM) structural protein (wolframin), is essential for several biological processes. Mutations of WFS1, autosomal dominant or recessive inherited, are related to a broad clinical spectrum. Molecular genetic tests were performed, and clinical phenotypes of three WFS1‐associated cases were
Juan-juan Zhang, Tong-tong Dai, Jun-qi Wang, Ming-yue Yin, Yuan-yan Yang, Li Jiang, Bei-jun Xia, Zhuo-zhou Cui, Wen-li Lu, Rong-gui Hu, Chuan-yin Li, Zhi-ya Dong, Yuan Xiao, Rasha Hamza   +13 more
wiley   +1 more source

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]

, 2009
OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...
Timpson, NJ, David P. Strachan, Weedon, Michael N., Weedon, MN, Nicholas J. Timpson, Rayner, NW, Morris, Andrew D., Zeggini, Eleftheria, Mark Walker, Alex S.F. Doney, Doney, ASF, Palmer, Colin N A, Timothy M. Frayling, Strachan, David P., Hitman, Graham A., Lindgren, Cecilia M., Hattersley, Andrew T., Hitman, GA, Lindgren, CM, Randall, Joshua, Doney, Alex S. F.; id_orcid, Graham A. Hitman, Andrew T. Hattersley, Walker, Mark, Palmer, CN, Hattersley, AT, Rayner, N. William, McCarthy, MI, Timpson, Nicholas J., Michael N. Weedon, Willem H. Ouwehand, Palmer, CNA, Walker, M, Andrew D. Morris, Doney, Alex S F, N. William Rayner, Lindgren, Cecilia, Randall, J, Mark I. McCarthy, Frayling, Timothy M., Strachan, DP, Morris, AD, Cecilia M. Lindgren, Doney, AS, Joshua Randall, McCarthy, Mark I., Zeggini, E, Eleftheria Zeggini, Ouwehand, WH, Pamler, CAN, Ouwehand, Willem H., Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +53 more
core   +1 more source

Factors Affecting Resilience and Prevention of Alzheimer's Disease and Related Dementias

Annals of Neurology, Volume 96, Issue 4, Page 633-649, October 2024.
Alzheimer's disease (AD) is a devastating, age‐associated neurodegenerative disorder and the most common cause of dementia. The clinical continuum of AD spans from preclinical disease to subjective cognitive decline, mild cognitive impairment, and dementia stages (mild, moderate, and severe).
Arjun V. Masurkar, Karyn Marsh, Brianna Morgan, Dominique Leitner, Thomas Wisniewski   +4 more
wiley   +1 more source

Sodium-potassium ATPase β1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress

, 2008
Wolfram syndrome, an autosomal recessive disorder characterized by diabetes mellitus and optic atrophy, is caused by mutations in the WFS1 gene encoding an endoplasmic reticulum (ER) membrane protein, Wolframin. Although its precise functions are unknown,
Rutter, GA, Fenton, SL, Ricketts, C, Barrett, Timothy; id_orcid, da Silva Xavier, G; id_orcid, Hofmann-Thiel, S, Zatyka, Malgorzata; id_orcid, Minton, JAL   +7 more
core   +1 more source

Functional Innovation in the Evolution of the Calcium-Dependent System of the Eukaryotic Endoplasmic Reticulum

Frontiers in Genetics, 2020
The origin of eukaryotes was marked by the emergence of several novel subcellular systems. One such is the calcium (Ca2+)-stores system of the endoplasmic reticulum, which profoundly influences diverse aspects of cellular function including signal ...
Daniel E. Schäffer, Daniel E. Schäffer, Lakshminarayan M. Iyer, A. Maxwell Burroughs, L. Aravind   +4 more
doaj   +1 more source

Anatomical and electrophysiological analysis of the fasciola cinerea of the mouse hippocampus

Hippocampus, Volume 34, Issue 10, Page 528-539, October 2024.
Abstract The hippocampus is considered essential for several forms of declarative memory, including spatial and social memory. Despite the extensive research of the classic subfields of the hippocampus, the fasciola cinerea (FC)—a medially located structure within the hippocampal formation—has remained largely unexplored.
Ioannis S. Zouridis, Giuseppe Balsamo, Patricia Preston‐Ferrer, Andrea Burgalossi   +3 more
wiley   +1 more source

Diabetes mellitus and pregnancy in Wolfram syndrome type 1: a case report with review of clinical and pathophysiological aspects

Frontiers in Medicine
Wolfram syndrome type 1 (WS1) is a rare genetic disorder characterized primarily by non-autoimmune diabetes mellitus, optic atrophy, deafness, and diabetes insipidus.
Amelia Caretto, Francesca Scarascia Mugnozza, Fanny Valsecchi, Erika Pedone, Mirko Pozzoni, Susanna Rosa, Andrea Laurenzi, Andrea Laurenzi, Giulio Frontino, Raniero Chimienti, Raniero Chimienti, Lorenzo Piemonti, Lorenzo Piemonti, Marina Scavini   +13 more
doaj   +1 more source