Results 71 to 80 of about 1,110,051 (352)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cultural shifts

eLife, 2018
China’s one-child policy has resulted in scientists with families having experiences that are very different to those elsewhere in the world.
Bridget M Kuehn
doaj   +1 more source

The Study of Cultural Globalization and Men's Attitude towards Women's Role Case Study: Men in Shiraz [PDF]

زن در فرهنگ و هنر, 2013
The purpose of the present study is to examine relationship between cultural globalization and men's attitude toward the role of women. The method of this study was survey and its tool was questionnaire.
Bijan khajenoori, Leila Parnian, Soghra Hemmat   +2 more
doaj   +1 more source

Trajetórias de mulheres na ciência: "ser cientista" e "ser mulher" Paths of women in science: "being a scientist" and "being a woman"

, 2014
The article discusses the academic and professional history of women in science. The production of interviews with women scientists working in public universities and in a research institution in Rio Grande do Sul is the corpus of analysis in this study.
F. D. Silva, P. Regina, C. Ribeiro
semanticscholar   +1 more source

Sally Ride Science Festival photographs and related material, 2005

, 2020
https://deepblue.lib.umich.edu/bitstream/2027.42/155380/2/objects.ziphttps://deepblue.lib.umich.edu/bitstream/2027.42/155380/4/metadata ...
University of Michigan. Women in Science and Engineering Program.
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Characterization of placental and decidual cell development in early pregnancy loss by single-cell RNA sequencing

Cell & Bioscience, 2022
Background Early pregnancy loss (EPL) presents as sporadic or recurrent miscarriage during the first trimester. In addition to chromosomal defects, EPL may result from impairment of the placental-decidual interface at early gestational age due to gene ...
Yuhua Zheng, Jing Pan, Chenglai Xia, Haiying Chen, Huadong Zhou, Weina Ju, Jerzy Wegiel, Leslie Myatt, James M. Roberts, Xiaoling Guo, Nanbert Zhong   +10 more
doaj   +1 more source

Photographs and videos

, 2020
https://deepblue.lib.umich.edu/bitstream/2027.42/155367/2/objects.ziphttps://deepblue.lib.umich.edu/bitstream/2027.42/155367/4/metadata ...
University of Michigan. Women in Science and Engineering Program.
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Underrepresentation of women in the senior levels of Brazilian science

PeerJ, 2017
Despite significant progress, there is still a gender gap in science all over the world, especially at senior levels. Some progressive countries are recognizing the need to address barriers to gender equality in order to retain their best scientists and ...
J. Valentova, E. Otta, Maria Luisa Santos Silva, A. McElligott   +3 more
semanticscholar   +1 more source