Results 81 to 90 of about 1,110,051 (352)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
The soil science discipline has undergone significant changes since its establishment in the 1900s; from strong connections with agronomy to a broader focus on ecosystems, earth, and environmental sciences while also during this period experiencing a ...
K. Vaughan +7 more
semanticscholar +1 more source
https://deepblue.lib.umich.edu/bitstream/2027.42/155371/2/objects.ziphttps://deepblue.lib.umich.edu/bitstream/2027.42/155371/4/metadata ...
University of Michigan. Women in Science and Engineering Program.
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
https://deepblue.lib.umich.edu/bitstream/2027.42/155386/2/objects.ziphttps://deepblue.lib.umich.edu/bitstream/2027.42/155386/4/metadata ...
University of Michigan. Women in Science and Engineering Program.
core
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
From the first glucose biosensor from Updike and Hicks (1968), there was an explosion of research in biosensors for detecting a wide range of analytes [...]
openaire +3 more sources
Oral History Interview, Graduate Women In Science (1241)
In their June 2012 interview with Troy Reeves and Vicki Tobias, Tina Hill, Tess Killpack, Christina Locke and Amanda Pertzborn discussed their participation in both Beta and National Chapters of GWiS (Graduate Women in Science).
Graduate Women In Science
core
https://deepblue.lib.umich.edu/bitstream/2027.42/155372/2/objects.ziphttps://deepblue.lib.umich.edu/bitstream/2027.42/155372/4/metadata ...
University of Michigan. Women in Science and Engineering Program.
core
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source

