Results 61 to 70 of about 195,879 (260)

Intrinsically regulated learning is modulated by synaptic dopamine signaling

eLife, 2018
We recently provided evidence that an intrinsic reward-related signal—triggered by successful learning in absence of any external feedback—modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain ...
Pablo Ripollés, Laura Ferreri, Ernest Mas-Herrero, Helena Alicart, Alba Gómez-Andrés, Josep Marco-Pallares, Rosa Maria Antonijoan, Toemme Noesselt, Marta Valle, Jordi Riba, Antoni Rodriguez-Fornells   +10 more
doaj   +1 more source

Learning to Compose Words into Sentences with Reinforcement Learning

CoRR, 2016
We use reinforcement learning to learn tree-structured neural networks for computing representations of natural language sentences. In contrast with prior work on tree-structured models in which the trees are either provided as input or predicted using supervision from explicit treebank annotations, the tree structures in this work are optimized to ...
Yogatama, D, Blunsom, P, Dyer, C, Grefenstette, E, Ling, W   +4 more
openaire   +5 more sources

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

An ERP Investigation of L2–L1 Translation Priming in Adult Learners

Frontiers in Psychology, 2018
A longstanding debate centers around how beginning adult bilinguals process words in their second language (L2). Do they access the meaning of the L2 words directly or do they first activate the native language (L1) translation equivalents in order to ...
Gabriela Meade, Katherine J. Midgley, Phillip J. Holcomb   +2 more
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Modeling Progressive Brain Volume Losses in Chronic Moderate Severe Traumatic Brain Injury: Extensive, but Attenuating

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progressive brain atrophy has now been widely observed in the chronic stages of moderate–severe traumatic brain injury (msTBI), but there is only coarse information regarding its prevalence and magnitude, and whether rate of atrophy accelerates or attenuates across time. We examined these questions in a Canadian inception cohort from
Robin E. A. Green, Brenda Colella, Alana Changoor, David J. Mikulis, Adrienne Li, Kadeen Johns, Georges A. Monette   +6 more
wiley   +1 more source

Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Francesca V. Lopez, Fareshte Erani, Katherine J. Bangen, David G. Coughlin, Douglas Galasko, Kelsey R. Thomas   +5 more
wiley   +1 more source

Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop

eLife, 2016
Humans constantly learn in the absence of explicit rewards. However, the neurobiological mechanisms supporting this type of internally-guided learning (without explicit feedback) are still unclear.
Pablo Ripollés, Josep Marco-Pallarés, Helena Alicart, Claus Tempelmann, Antoni Rodríguez-Fornells, Toemme Noesselt   +5 more
doaj   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

When the syntactic bootstrap breaks: Some children think any means no

Glossa
Children can use distributional information about where words occur to figure out their meanings. But what happens when two very different words not only have most of their distribution in common, but also compose to form indistinguishable sentential ...
Caitlin Illingworth, Haley Gibbs, Jee Won Diane Kang, Kathryn Davidson, Roman Feiman   +4 more
doaj   +2 more sources