Results 61 to 70 of about 1,076,695 (268)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Work-Family Conflict and Facilitation among Employees in Hong Kong
, 2014 Work-family imbalance can induce negative consequences, such as poor physical and psychological well-being for individuals. Hong Kong employees commonly agree that work-family balance is important for them, but it is difficult to balance work and family
Wong, Chi Kin
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Work-family Conflict and Organisational Commitment in Malaysia
, 2014 This study examined the relationship between work-family conflict (WFC) and organisational commitment, and considered gender and number of dependents as moderators.
Siu, Yen Pin
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Effect of Work-Family Conflict and Family-Work Conflict on Individual Job Performance in Nurses
Sağlık ve Hemşirelik Yönetimi DergisiAim: This study was conducted to determine the effect of work-family and family-work conflict levels of nurses on their individual job performance. Method: The sample of this descriptive and correlational design study consisted of 305 nurses.
Fatmanur Karaman +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Frontiers in Psychology, 2020 In a modern working environment characterized by new technology and work assignments extended to personal time, employees are expected to balance multiple roles while maintaining maximum productivity.
Bojan Obrenovic +3 more
doaj +1 more source
Qualitative study of work-family conflict in managerial couples, A. Are we overlooking some fundamental questions? [PDF]
In this study I explore the phenomenon of work-family conflict in an "unconventional" way. Most studies on work-family conflict are quantitative studies of individuals, based on Anglo-Saxon samples.
Poelmans, Steven
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source