Results 81 to 90 of about 2,573,191 (267)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Job Demands, Engagement, and Turnover Intentions in Polish Nurses: The Role of Work-Family Interface

Frontiers in Psychology, 2016
Background: Poland has lower ratios of employed registered nurses per 1,000 inhabitants than the EU average. Polish nurses work under miserable conditions without assisting personnel, and they reconcile their professional demands with responsibilities ...
Anna Maria Dåderman, Beata Aleksandra Basinska, Beata Aleksandra Basinska   +2 more
doaj   +1 more source

Single Mothers, Social Capital, and Work-Family Conflict [PDF]

The purpose of this paper is to examine work-family conflict among low-income, unmarried mothers. I examine how social capital affects work-family conflict and how both social capital and work-family conflict affect employment.
Teresa Ciabattari
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Pengaruh Work-family Conflict dan Stres Kerja terhadap Kepuasan Kerja dan Turnover Intention Karyawan Wanita [PDF]

, 2016
Penelitian ini bertujuan untuk mengetahui pengaruh work-family conflict dan stres kerja terhadap kepuasan kerja dan turnover intention karyawan wanita pada Bank Rakyat Indonesia (BRI) Kantor Cabang Gatot Subroto Denpasar.
Rahyuda, A. G. (Agoes), Sudibya, I. G. (I), Yani, N. W. (Ni)   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Burnout and inter-role conflict in telework: a gendered resource erosion pathway via job crafting

Frontiers in Psychology
IntroductionWhile the impact of work–family conflict (WFC) and family–work conflict (FWC) on employee well-being is well documented, less is known about how burnout may, in turn, increase these conflicts through diminished self-regulatory capacity in a ...
Jesus Yeves, Jesus Yeves, Laura Trujillo, Mariana Bargsted, Mariana Bargsted, Andy Luis Marrero-Vega, Andy Luis Marrero-Vega, Andy Luis Marrero-Vega   +7 more
doaj   +1 more source

Perceived workplace culture as an antecedent of job stress : the mediating role of work-family conflict. [PDF]

, 2010
Few studies have tested the mediating effect of work-family conflict on the relationship between workplace culture and job stress. Approach: This study tested a mediation model consisting of job stress as the dependent variable, perceived family ...
Ahmad, Aminah, Omar, Zoharah
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Family-friendly Policies Terhadap Work-family Conflict Serta Implikasinya Pada Komitmen Karyawan [PDF]

, 2013
The objectives of this study is to find out the influence of family-friendly policies on work-family conflict, the influence of work-family conflict on employee commitment, the influence of family-friendly policies on employee commitment, the ...
-, S. (SURVIVAL), NURHAYATI, I. D. (INDAH)   +1 more
core   +2 more sources