Results 91 to 100 of about 19,721,880 (260)

Work-family conflict and toddler parenting : a dynamic approach to the role of parents’ daily work–family experiences in their day-to-day parenting practices through feelings of parental emotional exhaustion

, 2023
The objective of this study was to examine associations between daily fluctuations in work-family conflict (i.e. work-to-family interference [WFI] and family-to-work interference [FWI]) and daily fluctuations in toddler parenting (i.e.
Mabbe, ElienPP070001108563478020010418750000-0002-9388-646634241F5C-F0EE-11E1-A9DE-61C894A0A6B4, Brenning, KatrijnPP070020031035508020004124860000-0003-4604-3156FAE4B008-F0ED-11E1-A9DE-61C894A0A6B4, Soenens, BartPP078020000690470000-0003-1581-3656F87C74FE-F0ED-11E1-A9DE-61C894A0A6B4   +2 more
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Family Policy, Perceived Stress and Work-Family Conflict A Comparative Analysis of Women in 20 Welfare States [PDF]

In what ways can family policy institutions be linked to women’s perceived stress and work-family conflict? This study combines new institutional information, enabling a multi-dimensional analysis of family policy legislation, with micro data on ...
Esser, Ingrid, Ferrarini, Tommy
core  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Predicting Work-Family and Familywork Conflict from Work and Family Domain: A Longitudinal Study

International Journal of Management Studies, 2012
Although work-family conflict studies are available in Malaysia, most rely on cross-sectional design and focus on women. This study uses the longitudinal design on a heterogeneous sample which is aimed to enhance the understanding of the antecedents of ...
Zaiton Hassan, Hana Hamidi
doaj  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Keeping Work and Family Separate: A Serial Mediation Analysis of Social Workers’ Work–Family Segmentation, Work–Family Enrichment and Job Performance in Australia

, 2020
With increased blurring of boundaries between work and family lives, work–family segmentation has been suggested as an effective work–life strategy for social workers who are involved in complex human service work, to reduce work–family conflict and ...
Kalliath, Thomas, Chan, Xi Wen, Kalliath, Parveen, Parveen Kalliath, Thomas Kalliath, Xi Wen Chan   +5 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Community Demands and Resources and Work-Family Conflict: Case Study in Kuching Sarawak

International Journal of Management Studies, 2014
Most studies on work-life balance only examine work and family domains. While work is the only role in its domain, life consists of many aspects besides family. However, research on other roles is still very limited.
Zaiton Hassan, Nor Afiza Hasnan, Surena Sabil   +2 more
doaj