Results 111 to 120 of about 2,573,191 (267)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Effects of Work–Family Conflict and Facilitation Profiles on Work Engagement

Societies
Achieving the balance between work and family life needs a holistic viewpoint on how these two aspects interact. It poses a significant challenge due to its impact on individuals, organizations, and society.
Carla Carvalho, Lisete Mónico, Ana Pinto, Soraia Oliveira, Eduardo Leite   +4 more
doaj   +1 more source

Exploring the Relationship Between Work–Family Conflict, Family–Work Conflict and Job Embeddedness: Examining the Mediating Role of Emotional Exhaustion

Psychology Research and Behavior Management, 2023
Suad Dukhaykh Management Department, College of Business, King Saud University, Riyadh, 11451, Saudi ArabiaCorrespondence: Suad Dukhaykh, Email Sdukhaykh@ksu.edu.saPurpose: The purpose of this study is to examine the relationships between family–work ...
Dukhaykh S
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Employees’ Financial Insecurity and Health: The Underlying Role of Stress and Work–Family Conflict Appraisals

, 2018
Data from two longitudinal samples were utilized to elucidate underlying mechanisms of the well‐established relationship between financial insecurity and health outcomes, stemming from the theoretical rationale of conservation of resources and cognitive ...
Matthews, Russell A., Odle-Dusseau, Heather N., Wayne, Julie H.   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Analisis Pengaruh Konflik Peran Ganda, Disiplin Kerja, dan Lingkunganpkerja Terhadapnkinerja Karyawanp PT. Globalindopintimates di Klaten [PDF]

, 2019
The research to find out and describe the influence of either simultaneously of partial work-family conflict, work discipline and work environtment. The population was all employees PT. Globalindo Intimates Klaten totaled 1300.
Kustiyah, E. (Eny), Sulisvi, S. (Sulisvi), Widayanti, R. (Rochmi)   +2 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

PENGARUH KOMPENSASI, WORK-FAMILY CONFLICT, DAN STRES KERJA TERHADAP KEPUASAN KERJA SALESMAN PT CAHAYA SAKTI FURINTRACO (OLYMPIC GROUP) [PDF]

, 2015
WISESA ALIF PRIYAMBODO RAMADHAN. The Impact of Compensation, Work-Family Conflict, and Work Stress on Salesman Job Satisfaction in PT Cahaya Sakti Furintraco (OLYMPIC GROUP). Faculty of Economics State University of Jakarta. 2015.
RAMADHAN, WISESA ALIF PRIYAMBODO
core   +1 more source