Results 61 to 70 of about 681,182 (305)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Work-life balance and family friendly policies [PDF]

, 2013
This paper presents Australian and international research on work-life interaction. We review the work-life policies and practices that are likely to have the greatest impact on work-life outcomes, specifically reducing the negative impact of work on ...
Natalie Skinner
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Balancing and Conflict Between Work and Family Life of Sandwiched Caregivers: A Scoping Review

Safety and Health at Work
The aim of this scoping review was to advance our understanding of the balancing and conflict between work and family life experienced by sandwiched caregivers.
Ayumi Honda, Mayo Ono, Takahiro Nishida, Sumihisa Honda   +3 more
doaj   +1 more source

Work-family culture, work-family balance and perceived performance

Dimensión Empresarial, 2019
El presente estudio analiza la relación entre Cultura trabajo-familia, Equilibrio trabajo-familia y desempeño percibido de los trabajadores de una empresa de retail de la Región Metropolitana, basados en el Modelo de Organizaciones Saludables y Resilientes.
Andrés Eduardo Jiménez-Figueroa, Barbara León-Gonzalez, Melissa Poblete-Gajardo   +2 more
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Role resources and work-family enrichment: The role of work engagement

, 2010
The majority of work-family research has focused on negative spillover between demands and outcomes and between the work and family domains (e.g., work-family conflict; see review by Eby, Casper, Lockwood, Bordeaux, & Brinley, 2005).
Siu, Oi-Ling, Danny Lo, Bakker, Arnold B., Shi, Kan, Chen, Wei-qing, Brough, P, Siu, OL, Lu, Chang-Qin, Lo, Danny, Chang-qin Lu, Bakker, Arnold B, Brough, Paula, Michael O'Driscoll, O’Driscoll, Michael P., Chen, WQ, Sit, C, Chen, W, Shi, K, Arnold B. Bakker, Cindy Sit, Kalliath, Thomas, Siu, Oi Ling, Jia-fang Lu, Bakker, Arnold, Phillips, David R., Thomas Kalliath, O'Driscoll, M, Oi-ling Siu, Phillips, DR, Lu, C, Siu, O, O'Driscoll, Michael, Bakker, Arnold; id_orcid, Kalliath, T, David R. Phillips, Lu, J, Phillips, David R, Bakker, AB, Lu, JF, Lo, D, Paula Brough, Sit, Cindy, O'Driscoll, Michael, Lu, Jia-fang, Kan Shi, Wei-qing Chen, Lu, CQ   +46 more
core   +1 more source

Contrasting Conceptions of Work–Family Balance and the Implications for Satisfaction with Balance during the COVID-19 Pandemic

Social Sciences
Pandemic-related changes, including the expansion of remote work and the closure of schools and daycare supports, posed unprecedented challenges to parents’ conceptions of their work and home routines. Drawing on interviews with 88 heterosexual partnered
Sejin Um, Anne Kou, Carolyn E. Waldrep, Kathleen Gerson   +3 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source