Results 71 to 80 of about 681,182 (305)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Influence of Work-Life Balance Benefits on Family-Supportive Organisational Perception and Work Attitudes

, 2010
This study investigated the relationship between the availability of, and the use of, work-family balance policies offered by organisations and family-supportive organisational perception (FSOP), work-to-family conflict, continuance and affective ...
Herlin, Paula Kristina
core  

Family-supportive organization perceptions, multiple dimensions of work-family conflict and employee satisfaction [PDF]

, 2008
Using samples of managers drawn from five Western countries, we tested a theoretical model linking employees’ perceptions of their work environment’s family-supportiveness to six different dimensions of work–family conflict (WFC), and to their job ...
Cooper, Cary L, Sanchez, Juan I, Brough, P, M. Lapierre, Laurent, I. Sanchez, Juan, Brough, Paula, O’Driscoll, Michael P., Sanchez, Juan I., Allen, Tammy D, O\u27Driscoll, Michael P., Allen, Tammy D., Spector, P E, Spector, Paul E, Lapierre, L M, Allen, T D, Cooper, C L; id_orcid, E. Spector, Paul, Kinnunen, U, Cooper, C L, Lapierre, Laurent M., O'Driscoll, M, Spector, Paul E., Sanchez, J I, Poelmans, Steven, Lapierre, Laurent M, Kinnunen, Ulla, P. O'Driscoll, Michael, Cooper, Cary L., L. Cooper, Cary, Poelmans, S, O'Driscoll, Michael P   +30 more
core   +1 more source

Leadership practices in relation to men's work-family balance in Finnish organizations

, 2021
Leadership practices in organizations play an important role in shaping the conditions for employees’ work-family balance. Previous research on the topic has mainly focused on women; fathers are said to receive little support from leadership for ...
Lämsä, Anna-Maija, Kangas, Emilia
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Work and Family Interface: Wellbeing and the Role of Resilience and Work-Life Balance

, 2012
Wellbeing research has recently gathered impetus largely due to the emergence of positive psychology. Researchers and practitioners are now exploring the science of positive subjective experiences, positive traits, positive states, aspects of human ...
Riley, Derek
core  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Mompreneurs, Leaning In and Opting Out: Work/Family Choices under Neo-Liberalism

Atlantis, 2017
This article explores three trends in the search for work-life balance and relates these trends to the neoliberal family policy context in Canada. I argue that these models reflect current ideologies about motherhood, the state, and work.
Shauna Wilton
doaj