Results 91 to 100 of about 3,236,631 (398)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Pengaruh Work-family Conflict dan Stres Kerja terhadap Kepuasan Kerja dan Turnover Intention Karyawan Wanita [PDF]

, 2016
Penelitian ini bertujuan untuk mengetahui pengaruh work-family conflict dan stres kerja terhadap kepuasan kerja dan turnover intention karyawan wanita pada Bank Rakyat Indonesia (BRI) Kantor Cabang Gatot Subroto Denpasar.
Rahyuda, A. G. (Agoes), Sudibya, I. G. (I), Yani, N. W. (Ni)   +2 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Work-Family Conflict Scale (ISSP)

, 2016
ZIS - The Collection Items and Scales for the Social ...
Breyer, Bianka, Bluemke, Matthias
openaire   +2 more sources

The New Male Mystique [PDF]

, 2011
Examines the rise in men reporting work-family conflict, factors that put men at risk for conflict, and those that help reduce it, including supervisor support and workplace flexibility.
Ellen Galinsky, Kenneth Matos, Kerstin Aumann   +2 more
core  

Work-Family Conflict and Worker’s Performance during Covid-19 Pandemic: What is the Role of Readiness to Change Mentality?

, 2020
This study aimed to measure the effect of work-family conflict on employee performance of the part-time employee of a packaging industry in Tangerang which are mediated by readiness for change.
Dewiana Novitasari, Ipang Sasono, Masduki Asbari   +2 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Effect of Work-Family Conflict and Family-Work Conflict on Individual Job Performance in Nurses

Sağlık ve Hemşirelik Yönetimi Dergisi
Aim: This study was conducted to determine the effect of work-family and family-work conflict levels of nurses on their individual job performance. Method: The sample of this descriptive and correlational design study consisted of 305 nurses.
Fatmanur Karaman, Ülkü Baykal, Seyhan Çerçi   +2 more
doaj   +1 more source

Work-Family conflict among hotel housekeepers in the Balearic Islands (Spain) [PDF]

, 2022
Xènia Chela-Àlvarez, Esther García Buades, Victòria Aurora Ferrer Pérez, Oana Bulilete, Joan Llobera   +4 more
openalex   +1 more source