Results 71 to 80 of about 17,538,337 (258)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Review of government initiatives for reconciling work and family life [PDF]

, 2015
Presents a review of government initiatives that help families balance their work and family responsibilities, highlighting innovative ideas and including a discussion of international trends and themes. Summary This AIFS Research Report presents a
Jennifer Baxter, Jennifer Renda
core  

The Effect of Work-Family Conflict and Family-Work Conflict on Individual Job Performance in Nurses

Sağlık ve Hemşirelik Yönetimi Dergisi
Aim: This study was conducted to determine the effect of work-family and family-work conflict levels of nurses on their individual job performance. Method: The sample of this descriptive and correlational design study consisted of 305 nurses.
Fatmanur Karaman, Ülkü Baykal, Seyhan Çerçi   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Qualitative study of work-family conflict in managerial couples, A. Are we overlooking some fundamental questions? [PDF]

In this study I explore the phenomenon of work-family conflict in an "unconventional" way. Most studies on work-family conflict are quantitative studies of individuals, based on Anglo-Saxon samples.
Poelmans, Steven
core  

Pengaruh Konflik Pekerjaan dan Konflik Keluarga Terhadap Kinerja dengan Konflik Pekerjaan Keluarga Sebagai Intervening Variabel (Studi pada Dual Career Couple di Jabodetabek)

Jurnal Manajemen dan Wirausaha, 2010
The purpose of this research is finding how the influence of working conflict towards family conflict, the influence of working conflict to working family conflict, the influence of family conflict to working family conflict and the influence of working ...
Christine W.S., Megawati Oktorina, Indah Mula   +2 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Burnout and inter-role conflict in telework: a gendered resource erosion pathway via job crafting

Frontiers in Psychology
IntroductionWhile the impact of work–family conflict (WFC) and family–work conflict (FWC) on employee well-being is well documented, less is known about how burnout may, in turn, increase these conflicts through diminished self-regulatory capacity in a ...
Jesus Yeves, Jesus Yeves, Laura Trujillo, Mariana Bargsted, Mariana Bargsted, Andy Luis Marrero-Vega, Andy Luis Marrero-Vega, Andy Luis Marrero-Vega   +7 more
doaj   +1 more source