Results 91 to 100 of about 2,576,793 (309)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Burnout and inter-role conflict in telework: a gendered resource erosion pathway via job crafting

Frontiers in Psychology
IntroductionWhile the impact of work–family conflict (WFC) and family–work conflict (FWC) on employee well-being is well documented, less is known about how burnout may, in turn, increase these conflicts through diminished self-regulatory capacity in a ...
Jesus Yeves, Jesus Yeves, Laura Trujillo, Mariana Bargsted, Mariana Bargsted, Andy Luis Marrero-Vega, Andy Luis Marrero-Vega, Andy Luis Marrero-Vega   +7 more
doaj   +1 more source

Perceived workplace culture as an antecedent of job stress : the mediating role of work-family conflict. [PDF]

, 2010
Few studies have tested the mediating effect of work-family conflict on the relationship between workplace culture and job stress. Approach: This study tested a mediation model consisting of job stress as the dependent variable, perceived family ...
Ahmad, Aminah, Omar, Zoharah
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Family-friendly Policies Terhadap Work-family Conflict Serta Implikasinya Pada Komitmen Karyawan [PDF]

, 2013
The objectives of this study is to find out the influence of family-friendly policies on work-family conflict, the influence of work-family conflict on employee commitment, the influence of family-friendly policies on employee commitment, the ...
-, S. (SURVIVAL), NURHAYATI, I. D. (INDAH)   +1 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Women at work: work family conflict and well being [PDF]

, 2008
Many women have diverted from their traditional single role as home makers who are financially dependent on their husbands to the double roles of being home makers and wage earners.
Sandhu, Sarvinder Kaur
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Neuroticism, work demands, work-family conflict and job stress consequences

Medycyna Pracy, 2014
Background: The objective of the study was to the determine of neuroticism, requirements of the labor market and work-family conflict while exploring consequences of various aspects of job stress in occupationally active parents.
Bogusława Halina Lachowska
doaj   +1 more source

Antecedent, Consequence and Moderator Factors of Work-Family Conflict Among Woman Academicians in Yogyakarta, Indonesia [PDF]

, 2000
Married working women play multiple roles as Wives, mothers, homemakers and employees, simultaneously. However, employers tend to view employees' problems related to work and family roles separately.
Hardyastuti, Suhatmini
core