Results 71 to 80 of about 88,550,665 (246)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Work and Family Interface: Wellbeing and the Role of Resilience and Work-Life Balance [PDF]

, 2012
Wellbeing research has recently gathered impetus largely due to the emergence of positive psychology. Researchers and practitioners are now exploring the science of positive subjective experiences, positive traits, positive states, aspects of human ...
Riley, Derek
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Work-Family Enrichment [PDF]

, 2022
What is work-family enrichment? Work-family enrichment is used to describe the positive benefits derived from spillover between work and family. Specifically, work-family enrichment is formally defined as “the extent to which experiences in one role ...
Stepanek, Sarah, Paul, Megan
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Linking Work-Family Enrichment to Job Satisfaction through Job Well-Being and Family Support: A Moderated Mediation Analysis of Social Workers across India

, 2018
Social workers often experience stress from competing work and family demands, which negatively affects their job well-being and subsequently their job satisfaction. Yet, social workers can experience enrichment from participating in both work and family
Chan, Christopher, Kalliath, Thomas, Chan, Xi wen, Parveen Kalliath, Christopher Chan, Chan, Christopher C. A., Thomas Kalliath, Kalliath, Parveen, Xi Wen Chan   +8 more
core   +1 more source

The development of the MACE work-family enrichment instrument

SA Journal of Industrial Psychology, 2013
Orientation: An instrument based on a theoretical model is necessary to measure the positive side of the work-family interface. Research purpose: To develop items for measurement of work-family enrichment based on the elements contained within a ...
Marissa de Klerk, Jan Alewyn Nel, Carin Hill, Eileen Koekemoer   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Good marriage at home, creativity at work: Family–work enrichment effect on workplace creativity

, 2017
To advance the understanding of socio-relational sources of employee creativity, we investigate the effect of a good marriage on workplace creativity.
Tang, Y, Xu Huang, Yongli Wang, Wang, Y, Huang, X, Yipeng Tang   +5 more
core   +1 more source