Results 141 to 150 of about 3,063,204 (302)

Envelhecimento funcional e condições de trabalho em servidores forenses

Revista de Saúde Pública
OBJETIVO: Avaliar o envelhecimento funcional (capacidade para o trabalho) associado às condições de trabalho. MÉTODOS: Responderam ao questionário "Índice de Capacidade para o Trabalho" (ICT), 807 servidores de uma instituição judiciária federal.
Silvia Meirelles Bellusci, Frida Marina Fischer   +1 more
doaj  

Application of Functional Capacity Evaluation in Return-to-work Ability Assessment of Work-related Injury Patients with Local Factures

康复学报, 2019
Objective:To explore the predictive validity of Functional Capacity Evaluation(FCE)on the employment status of work-related injured patients at different injured sites, and to explore the effect of pain on the predictive validity.Methods:A total of 300 ...
Ru HUANG, Xunwen LU, Yanwen XU, Huiling ZHOU   +3 more
doaj  

Australia’s response to the Horn of Africa humanitarian crisis, 2011 [PDF]

An evaluation by the Office of Development Effectiveness of Australia’s response to the Horn of Africa humanitarian crisis, 2011. Foreword This report identifies many strengths of the Australian response to the humanitarian crisis in the Horn of ...
Anais Resseguier, Deborah Clifton, Hugo Slim, Joyce Njagi, Karen Ovington, Lewis Sida, Shams Tazi   +6 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

[Work capacity evaluation in inorganic lead exposure].

Arhiv za higijenu rada i toksikologiju, 1991
When estimating the work ability of workers exposed to inorganic lead four zones should be differentiated: a zone of normal exposure (I), a zone of abnormal but acceptable exposure (II), a zone of abnormal but still acceptable exposure (III) and a zone of abnormal and unacceptable exposure (IV).
L, Kurajica, M, Orlov
openaire   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Early career research capacity-building for the health and social care workforce: process evaluation of internships and fellowships provided through a research-practice partnership. [PDF]

Health Res Policy Syst
Elvey R, Atkinson R, Twelvetree T, Lewis P.   +3 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source