Results 111 to 120 of about 1,698,497 (308)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Developing the influence of discipline and work motivation on the performance of educators in the student guidance section

JPPI (Jurnal Penelitian Pendidikan Indonesia)
The purpose of this study was to determine how much influence discipline and work motivation have on teacher performance. The population in this study were 78 teachers at Setukpa Lemdikpol Sukabumi who worked in the student guidance section.
Hesri Mintawati, Asep Hikmat, Kohar Pradesa, Idha Gusmara   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Pengaruh Disiplin, Pendidikan dan Lingkungan Kerja terhadap Kinerja Karyawan di Supermarket Pamella Satu Kota YOGYAKARTA [PDF]

, 2015
This research have purpose to a) know effect discipline toward employees performance, b) know effect education toward employees performance, c) know effect work environment toward employees performance, d) know effect discipline, education, and work ...
Herawati, V. M. (Vernita)
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

THE INFLUENCE OF WORK DISCIPLINE AND WORK ENVIRONMENT ON ORGANIZATIONAL COMMITMENT EMPLOYEE OF SBU ENERGY AT PT BIRO KLASIFIKASI INDONESIA (PERSERO) NORTH JAKARTA

Jurnal Riset Manajemen Sains Indonesia, 2017
The purpose of this research are: 1) To know the description for the work dicipline, work environment and organizational commitment employee of SBU Energy at PT Biro Klasifikasi Indonesia (Persero) North Jakarta, 2) To know the influence work dicipline ...
Dewi Susita, Wahiddah Muslimah, Agung AWS Waspodo   +2 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

EFEKTIVITAS IMPLEMENTASI SI-PRETI DALAM MENINGKATKAN KEDISPILINAN ASN DI BADAN KEPEGAWAIAN DAN PENGEMBANGAN SUMBER DAYA MANUSIA KOTA MALANG [PDF]

The purpose of this study was to measure the effectiveness of SI-PRETI implementation in improving ASN discipline in BKPSDM Malang City. As for the background of this study, researchers found that to realize civil servants with integrity, it is necessary
Yani, Sri Husda
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source