Results 131 to 140 of about 95,733 (264)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

The Influence of Work Environment, Work Stress, and Work Discipline on Work Achievement

open access: yesIndonesian Interdisciplinary Journal of Sharia Economics
Success in building good governance in an agency is highly dependent on the support of quality human resources. The quality of human resources is directly proportional to the quality of work produced; the better the quality of human resources, the ...
Tri Mulyani Kartini   +1 more
doaj  

EFFECT OF WORK TRAINING, WORK MOTIVATION, AND WORK DISCIPLINE ON EMPLOYEE PERFORMANCE AT PT. X

open access: yes, 2023
This study aims to determine the effect of job training, work motivation, work discipline on employee performance. This research was conducted at PT.
Prakoso, Dimas, Syahrian, Syahrian
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Melampaui Motivasi: Bagaimana Stres Kerja dan Disiplin Kerja Membentuk Kinerja Karyawan pada Layanan Kurir

open access: yesJurnal Manajemen dan Bisnis Kreatif
This study examines declining employee performance driven by high inbound-related workloads, employee tardiness, low compliance with work regulations, and missed company-set targets.
Rival Bayu Prasetyo   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Impact of Work Overload Work Stress and Work Discipline on Employee Job Satisfaction

open access: yesJurnal Pamator
This research aims to determine the relationship between work overload, work stress, and work discipline in influencing job satisfaction. The study employs a quantitative approach as the research method.
Irma Galuh Septiany   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

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