Results 61 to 70 of about 333,989 (254)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Online Work-Family Enrichment Self-Efficacy Program: A Pilot Randomized-Controlled Trial

Psychological Topics
This paper explores the effectiveness of a newly developed online self-paced training program for work-family enrichment self-efficacy in a Lithuanian employees sample.
Tadas Vadvilavičius, Aurelija Stelmokienė   +1 more
doaj   +2 more sources

Employees’ work–family enrichment in leadership context: systematic review and meta-analytical investigation

Business: Theory and Practice
The aim of this study is to systematically summarize and analyse the relationship between work-family enrichment/family-work enrichment and family-supportive supervisor behaviour. A systematic literature review procedure was applied to search and review
Tadas Vadvilavičius, Aurelija Stelmokienė   +1 more
doaj   +1 more source

Positive Psychological Micro-Interventions to Improve the Work–Family Interface: Use Your Resources and Count Your Blessings

Frontiers in Psychology, 2020
The present study is designed to test the effectiveness of two positive psychological micro-interventions (“use your resources” and “count your blessings”) aimed at improving the combination of work and family roles.
Maria C. W. Peeters, Maria C. W. Peeters, Elianne F. van Steenbergen, Elianne F. van Steenbergen, Jan Fekke Ybema   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Work-Family Organizational Support as a Predictor of Work-Family Conflict, Enrichment, and Balance: Crossover and Spillover Effects in Dual-Income Couples

Europe's Journal of Psychology, 2020
Dual-income families are challenged by several issues in terms of conciliation between the working environment, the family context and the management of children.
Alessandro Lo Presti, Monica Molino, Federica Emanuel, Alfonso Landolfi, Chiara Ghislieri   +4 more
doaj   +1 more source

Reciprocation at work: the role of work to family enrichment and family role salience

E+M Ekonomie a Management, 2018
This study investigated the main and conditional indirect effects of emotional and instrumental family related social supports from coworkers on person and task focused interpersonal citizenship behavior (ICBs). We incorporated work to family enrichment as mediator and family role salience as moderator in conditional indirect effect paths. Primary data
Aneel Kumar, Khalil Ahmed Channa, Niaz Ahmed Bhutto   +2 more
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Work–family enrichment, job satisfaction, and work engagement: The mediating role of subjective career success

Australian Journal of Psychology, 2020
Objective: The aim of the study was to explore the possible indirect effect of subjective career success on the relationship between work–family enrichment and job satisfaction and work–family enrichment and work engagement.
Eileen Koekemoer, Chantal Olckers, Cherise Nel   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source