Results 71 to 80 of about 120,440 (291)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
202 Helvetica Physica Acta, Vol. 51 (1978), Birkhliuser Verlag, Basel Stochastic processes II:
, 2014 . Linear and nonlinear response theory are developed for stationary Markov systems describing systems in equilibrium and nonequilibrium. Generalized fluctuation theorems are derived which relate the response function to a correlation of nonlinear ...
Response Theory, Fluctuation Theorems
core
Case Studies in Thermal EngineeringStudying the effect of periodic airflow temperature on the heat dissipation of surrounding rock is the basis for revealing the causes of seasonal mine heat damage.
Mingyan Guo +5 more
doaj +1 more source
Science and Technology of Nuclear Installations, 2013 Under heaving movement conditions, the single phase flow instability in U-tubes is affected by the additional force, which will influence the marine reactor operation.
Jianli Hao, Wenzhen Chen, De Zhang
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Two-dimensional acoustic analysis using Taylor expansion-based boundary element method
Frontiers in PhysicsThe use of boundary elements in two-dimensional acoustic analysis is presented in this study, along with a detailed explanation of how to derive the final discrete equations from the fundamental fluctuation equations.
Yan Yang +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Nanometer Scale Atomic Structure of Zirconium Based Bulk Metallic Glass
, 2011 We have studied the nanometer scale structure of bulk metallic glass (BMG) using fluctuation electron microscopy (FEM). The nanometer scale medium range order (MRO) in BMG is of significant interest because of its possible relationship to the properties,
Hwang, Jinwoo
core
Railway Engineering Science, 2020 Increasing railway traffic and energy utilization issues prompt electrified railway systems to be more economical, efficient and sustainable. As regenerative braking energy in railway systems has huge potential for optimized utilization, a lot of ...
Xiaohong Huang +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source