Results 61 to 70 of about 120,440 (291)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Effect of swirl on fluctuation of pressure drop in a gas–liquid slug flow

open access: yesMeasurement: Sensors, 2020
Slug flow as one of the typical two-phase flow patterns occurs widely in industry. The fluctuating phenomenon in slug flow is harmful to the pipeline system and should be suppressed.
Wen Liu, Xiaofei Lv, Zhongchuang Zhao
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Modulated two-level system: Exact work statistics [PDF]

open access: yes, 2013
peer reviewedWe consider an open two-level system driven by a piecewise constant periodic field and described by a rate equation with Fermi, Bose, and Arrhenius rates, respectively. We derive an analytical expression for the generating function and large
VAN DEN BROECK, Christian   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Generalized Fokker-Planck equation and its solution for linear non-Markovian Gaussian systems

open access: yesCondensed Matter Physics, 2011
In this paper we suggest a consistent approach to derivation of generalized Fokker-Planck equation (GFPE) for Gaussian non-Markovian processes with stationary increments. This approach allows us to construct the probability density function (PDF) without
O.Yu. Sliusarenko
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Medium Range Order in High Aluminum Content Amorphous Alloys Measured by Fluctuation Electron Microscopy

open access: yes, 2007
High Al-content metallic amorphous alloys have an unusual devitrification behavior. Upon annealing, alloys made by a rapid quench develop a high density (>1021 m-3) of pure Al nanocrystals.
Stratton, William
core  

Summary measures of optimized gaits as a function of weighting α: Work cost, force fluctuation (fl.) cost, double support time (for walking) or leg duty factor (or ground contact time, for running) as fraction of stride, and peak vertical force.

open access: yes, 2015
As the optimization cost function is changed from work only (α = 0) to force fluctuation only (α = 1), the work cost increases and force fluctuation cost decreases, both monotonically. The resulting double support time and leg duty factor (ground contact
Arthur D. Kuo (181119)   +1 more
core   +1 more source

Alternation of amplitude of low⁃frequency fluctuation and functional connectivity in the patients of Parkinson's disease with working memory impairment: a resting⁃state fMRI study

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2020
Objective To explore the characteristics of resting⁃state amplitude of low⁃frequency fluctuation (ALFF) and functional connectivity (FC) in patients with Parkinson's disease (PD) and working memory impairment, and to explore its correlation with cognitive function in order to reveal the abnormal neuronal activity and possibility of brain regions ...
Wei⁃wen ZHANG   +5 more
openaire   +2 more sources

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