Results 151 to 160 of about 136,179,624 (307)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Working mothers and their multivoiced self

open access: yes, 2012
Since the 1960's, work has been a goal for Brazilian middle class women. In contrast, mothers of lower-income groups have always needed to work. This qualitative study investigated the meaning of motherhood, child care and work among 28 working mothers of different social classes. In order to do so, interviews and focus groups were conducted.
openaire   +2 more sources

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe   +7 more
wiley   +1 more source

Perceptions of family functioning and self-concept in adolescent anorexia nervosa

open access: yes, 2006
Authors have highlighted the importance of the family for the development of positive self-concept and identity, not only in mental health research but also in various developmental and social psychology fields.
Halse, Christine   +3 more
core  

Self-care readiness index [PDF]

open access: yes, 2021
Global Self-Care Federation, 2021
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Self-actualization at work

open access: yes, 2023
Die Betrachtung von Selbstverwirklichung und sinnvoller Arbeit einschließlich ihrer Potenziale für die die persönliche Entwicklung lassen sich bis hin zu den griechischen Philosophen zurück datiertieren. Aristoteles beschrieb eine ethisch sinnvolle, eudaimonische Lebensweise, die durch selbstbestimmte Aktivitäten und die Verwirklichung des höchsten ...
openaire   +1 more source

Home - About - Disclaimer - Privacy