Results 121 to 130 of about 16,598,865 (356)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The effective participation of the audience in the production of news: encouraging opportunities through data journalism [PDF]

, 2018
Digital tools allow and encourage users "to participate in the creation and circulation of media” (Lewis, 2012). This participation can be considered as a remedy against the growing disconnection between journalism and citizens, also as a formula for a ...
Blanco-Castilla, Elena Pilar, Teruel-Rodriguez, Laura   +1 more
core  

Exploring online health information seeking and sharing among older adults: a mini-review about acceptance, potentials, and barriers

Frontiers in Digital Health
Online health information seeking (OHIS) is understood by health care, health promotion, and disease prevention experts as a resource for healthy aging. It is particularly relevant for older adults since this population can benefit significantly from the
Yves Bachofner, Alexander Seifert, Samin Sepahniya, Carlo Fabian   +3 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Mapping community pathways to employment for youth with disabilities—a realist review

Frontiers in Public Health
Background and objectivesYouth with disabilities face significant challenges in accessing employment and transitioning from school-to-work settings. Youth in intersectional contexts face additional barriers.
Amelia Hagelstam-Renshaw, Roberta Cardoso, Jinan Zeidan, Ebrahim Mahmoudi, Linda Nguyen, Eleni Philippopoulos, Keiko Shikako   +6 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Navigating urban mobility: Mobility attitudes and travel mode choices in Dubai and Lahore

Transport Economics and Management
Understanding the complexities of urban travel behaviors is essential for fostering sustainable mobility systems. This study examines the impact of socio-economic factors, attitudinal variables, and urban characteristics on travel mode choices for ...
Abdul Ghaffar Chaudhry, Houshmand Masoumi, Hans-Liudger Dienel, Atif Bilal Aslam, Mariam Shahnaz, Muhammad Ahmad, Mehtab Hussain   +6 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Participation of Older Europeans in Volunteer Work [PDF]

Today’s discussion about the growing ‘burden of ageing’ must not neglect the substantial productive potential of the elderly population. Using micro-data from the new ‘Survey of Health, Ageing and Retirement in Europe’ (SHARE), we explore cross-national ...
Karsten Hank, Marcel Erlinghagen
core  

Political participation: the vocational motivations of Labour party employees [PDF]

, 2003
Party employees are an under-researched group in political science. This article begins to address this oversight by examining Labour Party employees using new quantitative and qualitative data.
Denver D., Jordan G., Justin Fisher, Norris P., Olson M., Paul Webb, Seyd P., Webb P., Webb P., Whiteley P., Wilson J. Q.   +10 more
core   +2 more sources