Results 81 to 90 of about 4,290,560 (312)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Synergizing urban and mobility governance: Insights from Dubai and Lahore

Journal of Urban Management
Urban centers in the Middle East and North Africa (MENA) and South Asian (SA) regions face challenges like urban sprawl, low-density development, and heavy investment in road infrastructure, worsened by fragmented governance and political instability ...
Abdul Ghaffar Chaudhry, Houshmand Masoumi, Hans-Liudger Dienel   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The effectiveness of vocational rehabilitation on work participation: a propensity score matched analysis using nationwide register data

Scandinavian Journal of Work, Environment & Health, 2019
OBJECTIVE: Research on the effectiveness of vocational rehabilitation has focused on small and selected groups, lacked proper controls, or not captured dynamic changes in work participation.
Taina Leinonen, Eira Viikari-Juntura, Kirsti Husgafvel-Pursiainen, Pirjo Juvonen-Posti, Mikko Laaksonen, Svetlana Solovieva   +5 more
doaj   +1 more source

Six shades of grey: Identifying drinking culture and potentially risky drinking behaviour in the grey zone between work and leisure. The WIRUS culture study

Journal of Public Health Research, 2019
Objectives: The aim of this study was to explore drinking culture and drinking situations that employers and employees encounter in the grey zone between work and leisure, and identify what might affect employees’ risky drinking behaviour.
Hildegunn Sagvaag, Silje Lill Rimstad, Liv Grethe Kinn, Randi Wågø Aas   +3 more
doaj   +1 more source

Memorandum on Bargaining Tactics, 1979 [PDF]

, 1979
Memo to all WCIRA consultants with 102 LRRM 1079-1080 attached discussing Arrow Molded Plastics Inc.
Ogden, Warren C
core   +1 more source

Working with Children with Learning Disabilities and/or who Communicate Non-verbally: Research experiences and their implications for social work education, increased participation and social inclusion [PDF]

, 2009
Social exclusion, although much debated in the UK, frequently focuses on children as a key 'at risk' group. However, some groups, such as disabled children, receive less consideration.
Anita Franklin, Barnes M., Beresford B., Beresford B., Beresford B., Cameron L., Clarke H., Dickens M., Kirby P., Kirby P., Knight A., Levitas R., Marchant R., Margaret Bell, McNeish D., Mitchell W., Morris J., Nolan M., Petrie P., Rix J., Veronica Greco, Wendy Mitchell, Willow C., Wilson K.   +23 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Exploring online health information seeking and sharing among older adults: a mini-review about acceptance, potentials, and barriers

Frontiers in Digital Health
Online health information seeking (OHIS) is understood by health care, health promotion, and disease prevention experts as a resource for healthy aging. It is particularly relevant for older adults since this population can benefit significantly from the
Yves Bachofner, Alexander Seifert, Samin Sepahniya, Carlo Fabian   +3 more
doaj   +1 more source