Results 91 to 100 of about 246,522 (302)

Introduction to Workflows – Part 2 [PDF]

Transformations
In this second part of the introduction to the first issue of Transformations. A DARIAH journal (dedicated to workflows), we present three articles, respectively dedicated to metadata-based, text-based and musicology workflows.
Anne Baillot, Françoise Gouzi, Toma Tasovac   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Fusion of computational and experimental provenance in RO-Crate

Journal of Integrative Bioinformatics
Modern research projects typically involve several measurement techniques and computational analyses, resulting in complex, multimodal research data objects.
Ott Caroline, Schneider Kevin, Weil Heinrich Lukas, Wetzels Florian, Zimmer David, Garth Christoph, Mühlhaus Timo   +6 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

myExperiment: a repository and social network for the sharing of bioinformatics workflows

myExperiment (http://www.myexperiment.org) is an online research environment that supports the social sharing of bioinformatics workflows. These workflows are procedures consisting of a series of computational tasks using web services performed on data ...
De Roure, David, Aleksejevs, Sergejs, Michaelides, Danius, Roos, Marco, Cruickshank, Don, Bhagat, Jiten, Newman, David, Goble, Carole, Li, Peter, Borkum, Mark, Bechhofer, Sean   +10 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Enforcing reputation constraints on business process workflows [PDF]

, 2014
The problem of trust in determining the flow of execution of business processes has been in the centre of research interst in the last decade as business processes become a de facto model of Internet-based commerce, particularly with the increasing ...
Benjamin Aziz, Aziz, Benjamin, Hamilton, Geoff, Geoff Hamilton   +3 more
core  

Verification of business process workflows

Technological and Economic Development of Economy, 2012
Modeling of Business processes is essential in many areas. Workflows represent the Business processes. It is possible to identify potential problems while performing verification of workflows.
Henrikas Pranevičius, Regina Misevičienė   +1 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source