Results 71 to 80 of about 246,522 (302)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

haesleinhuepf/napari-workflows: 0.2.10

, 2023
<h2>What's Changed</h2> <ul> <li>Bugfix filenames turned into image names by @haesleinhuepf in https://github.com/haesleinhuepf/napari-workflows/pull/37</li> </ul> <p><strong>Full Changelog</strong> ...
Johannes Soltwedel, Ryan Savill, Till Korten, Pradeep Rajasekhar, Robert Haase   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The bi-objective workflow satisfiability problem and workflow resiliency [PDF]

Journal of Computer Security, 2016
A computerized workflow management system may enforce a security policy, specified in terms of authorized actions and constraints, thereby restricting which users can perform particular steps in a workflow. The existence of a security policy may mean that a workflow is unsatisfiable, in the sense that it is impossible to find a valid plan (an ...
Jason Crampton, Gregory Z. Gutin, Daniel Karapetyan, Rémi Watrigant   +3 more
openaire   +5 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Tools for semi-automatic monitoring of industrial workflows

, 2010
This paper describes a tool chain for monitoring complex workflows. Statistics obtained from automatic workflow monitoring in a car assembly environment assist in improving industrial safety and process quality.
Thallinger, Georg, Bouchrika, Imed, Thaler, Marcus, Arbab-Zavar, Banafshe, Rene, Schuster, Middleton, Lee, Sabeur, Zoheir, Stalder, Severin, Albert, Hofman, Nixon, Mark, Grabner, Helmut, Veres, Galina, Carter, John, Van Gool, Luc, Morzinger, Roland   +14 more
core   +1 more source

Giving structure to the "everything else" box: Creating curation standards for qualitative data

IASSIST Quarterly
To produce high-quality data for future use, Curators must be both proactive in setting FAIR (Findability, Accessibility, Interoperability, and Reuse) standards and flexible in allowing curation standards to evolve alongside methodological and ...
Amanda Draft, Annie Beaubien, Zachary Bennett, Julie Eady, Aubrey Garman, Matthew Johnston   +5 more
doaj   +1 more source