Results 61 to 70 of about 133,713 (268)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Giving structure to the "everything else" box: Creating curation standards for qualitative data

IASSIST Quarterly
To produce high-quality data for future use, Curators must be both proactive in setting FAIR (Findability, Accessibility, Interoperability, and Reuse) standards and flexible in allowing curation standards to evolve alongside methodological and ...
Amanda Draft, Annie Beaubien, Zachary Bennett, Julie Eady, Aubrey Garman, Matthew Johnston   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The impact of open access publishing agreements at the University of Vienna in light of the Plan S requirements: a review of current status, challenges and perspectives

Insights: The UKSG Journal, 2020
The University of Vienna, in partnership with other organisations across Austria, has been at the forefront of the open access (OA) movement in Europe and has been actively broadening the OA publishing opportunities for its researchers for well over half
Rita Pinhasi, Brigitte Kromp, Guido Blechl, Lothar Hölbling   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Linked Data Approach to Sharing Workflows and Workflow Results [PDF]

, 2010
A bioinformatics analysis pipeline is often highly elaborate, due to the inherent complexity of biological systems and the variety and size of datasets. A digital equivalent of the 'Materials and Methods' section in wet laboratory publications would be highly beneficial to bioinformatics, for evaluating evidence and examining data across related ...
Marco Roos, Sean Bechhofer, Jun Zhao 0003, Paolo Missier, David R. Newman, David De Roure, M. Scott Marshall   +6 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Evaluation of guided reporting: quality and reading time of automatically generated radiology report in breast magnetic resonance imaging using a dedicated software solution

Diagnostic and Interventional Radiology
PURPOSE: Unstructured, free-text dictation (FT), the current standard in breast magnetic resonance imaging (MRI) reporting, is considered time-consuming and prone to error.
Martin H. Maurer, Daniel Lorenz, Maximilian Clemens Otterbach, Igor Toker, Alexander Huppertz   +4 more
doaj   +1 more source

Product Based Workflow Support: Dynamic Workflow Execution [PDF]

, 2008
Product Based Workflow Design (PBWD) is a successful new approach to workflow process support. A description of the product, the Product Data Model (PDM), is central to this approach. While other research so far has focused on deriving a process model from the PDM, this paper presents a way to directly execute the PDM.
Irene Vanderfeesten, Hajo A. Reijers, Wil M. P. van der Aalst   +2 more
openaire   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source