Results 81 to 90 of about 246,522 (302)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Optimal deployment of geographically distributed workflow engines on the Cloud [PDF]

, 2014
This research was pursued under the EPSRC ‘Working Together: Constraint Programming and Cloud Computing’ grant, a Royal Society Industry Fellowship ‘Bringing Science to the Cloud’, and an Amazon Web Services Education Research Grant.
Ozgur Akgun, Varghese, Blesson, Adam Barker, Miguel, Ian, Blesson Varghese, Akgun, Ozgur, Thai, Long, Long Thai, Ian Miguel, Barker, Adam   +9 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

fair-workflows/FAIRWorkflowsExtension: User Evaluation Version

, 2021
Jupyter Lab extension for use in User Evaluation of Fair Workflows ...
Sven van der Burg, dsmits, Robin Richardson   +2 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

myExperiment: Defining the Social Virtual Research Environment [PDF]

, 2008
The myExperiment Virtual Research Environment supports the sharing of research objects used by scientists, such as scientific workflows. For researchers it is both a social infrastructure that encourages sharing and a platform for conducting research ...
De Roure, David, Goderis, A, Newman, DR, Bhagat, Jiten, Antoon Goderis, Goderis, Antoon, David Newman, Goble, CA, Cruickshank, D, Don Cruickshank, Roure, DD, David De Roure, Danius Michaelides, Michaelides, DT, Michaelides, Danius, Cruickshank, Don, Carole Goble, Newman, David, Goble, Carole, Jiten Bhagat, Bhagat, J   +20 more
core   +1 more source

HUM häkaton 2026: loovad lahendused kultuuripärandi kasutamiseks ja vahendamiseks [PDF]

Mäetagused
HUM Data Lab operates as part of Estonia’s Research and Cultural Data Infrastructure. The lab aims to support data-intensive humanities research, the reuse of cultural data and the description of transparent and reproducible workflows.
Kaisa Langer
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Evaluation of guided reporting: quality and reading time of automatically generated radiology report in breast magnetic resonance imaging using a dedicated software solution

Diagnostic and Interventional Radiology
PURPOSE: Unstructured, free-text dictation (FT), the current standard in breast magnetic resonance imaging (MRI) reporting, is considered time-consuming and prone to error.
Martin H. Maurer, Daniel Lorenz, Maximilian Clemens Otterbach, Igor Toker, Alexander Huppertz   +4 more
doaj   +1 more source