Results 71 to 80 of about 4,234,681 (285)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Prevalence of Leishmania spp. infection in domestic dogs in Chapare, Bolivia.
, 2011 Data on Leishmania spp. infection in dogs in Bolivia is scarce. Dogs from an area where 90% of human cutaneous leishmaniasis (CL) cases are due to Leishmania (Viannia) braziliensis were screened for Leishmania infection using established enzyme-linked ...
Reithinger, Richard +11 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Dogs (Canis familiaris), but not chimpanzees (Pan troglodytes), understand imperative pointing [PDF]
, 2012 Chimpanzees routinely follow the gaze of humans to outside targets. However, in most studies using object choice they fail to use communicative gestures (e.g. pointing) to find hidden food.
Michael Tomasello (31692) +14 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Remission of histiocytic ulcerative colitis in Boxer dogs correlates with eradication of invasive intramucosal Escherichia coli [PDF]
, 2009 BACKGROUND: Historically, histiocytic ulcerative (HUC) (or granulomatous) colitis of Boxer dogs was considered an idiopathic immune-mediated disease with a poor prognosis. Recent reports of dramatic responses to enrofloxacin and the discovery of invasive
Dogan, B. +8 more
core
Working dogs transfer different tasks in reciprocal cooperation [PDF]
, 2018 Direct reciprocity can establish stable cooperation among unrelated individuals. It is a common assumption of direct reciprocity models that agents exchange like with like, but this is not necessarily true for natural interactions.
Nastassja Gfrerer +3 more
core +1 more source
Review of How Dogs Work and What is a Dog? [PDF]
Journal of Mammalogy, 2016 Coppinger, R., and M. Feinstein. 2015. How Dogs Work. University of Chicago Press, Chicago, Illinois, xii + 244 pp. + 8 pl. ISBN: 978-0-226-12813-9, price (cloth), $26. Coppinger, R., and L. Coppinger. 2016. What Is a Dog? University of Chicago Press, Chicago, Illinois, xviii + 258 pp. + 16 pl. ISBN: 978-0-226-12794-1, price (cloth), $30. Raymond and
openaire +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Can we continue research in splenectomized dogs? Mycoplasma haemocanis: Old problem - New insight [PDF]
, 2004 We report the appearance of a Mycoplasma haemocanis infection in laboratory dogs, which has been reported previously, yet, never before in Europe. Outbreak of the disease was triggered by a splenectomy intended to prepare the dogs for a hemorrhagic shock
Muenzing, S. +11 more
core +1 more source