Results 81 to 90 of about 4,234,681 (285)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Paedomorphic Facial Expressions Give Dogs a Selective Advantage [PDF]

, 2013
How wolves were first domesticated is unknown. One hypothesis suggests that wolves underwent a process of self-domestication by tolerating human presence and taking advantage of scavenging possibilities.
Caeiro, Cátia C., Kate Peirce, Waller Bridget M., Linda Scheider, Cátia C. Caeiro, Scheider, L, Anne M. Burrows (502427), Peirce, Kate, Sandra McCune (333196), Bridget M. Waller (137067), Burrows, AM, Juliane Kaminski (128853), McCune, S, Caeiro Cátia C., Burrows Anne M., Kaminski, J, Linda Scheider (214118), Burrows, Anne M., Caeiro, CC, Kaminski Juliane, Kaminski, Juliane, Anne M Burrows, Ra Mccune, McCune, Sandra, Cátia C Caeiro, Bridget M Waller, Annem Burrows, Cátia C. Caeiro (502426), Waller, Bridget M., Waller, BM, Peirce, K, Sandra McCune, Kate Peirce (137070), Juliane Kaminski, McCune Sandra, Scheider, Linda, Scheider Linda, Bridget M. Waller, Peirce Kate   +38 more
core   +1 more source

Balancing Objectivity and Welfare: Physiological and Behavioural Responses of Guide Dogs During an Independent Certification Protocol

Animals
Guide dogs are essential in supporting the autonomy of blind and visually impaired individuals. Austria is the first country to implement a legally mandated, two-stage certification protocol for the official recognition of guide dogs, assessed by an ...
Viola Faerber-Morak, Lisa-Maria Glenk, Karl Weissenbacher, Annika Bremhorst   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Wolves do not join the dance: Sophisticated aggression control by adjusting to human social signals in dogs [PDF]

, 2013
In this study we aimed to investigate novel aspects of dogs' comprehension of human social behaviours by revealing potential differences in the responses of wolves and dogs when they interact with a human in socially ambiguous situations. In Experiment 1,
Gácsi, Márta, Miklósi, Ádám, Topál, József, Vas, Judit   +3 more
core   +1 more source

Guide Dogs on Holiday: Guide dog owner experiences in the travel and tourism sector

, 2020
This report presents findings from research on the user experience of travelling with a guide dog. Working in collaboration with The Guide Dogs for the Blind Association, the objectives of the project were to investigate guide dog owner confidence in ...

core   +4 more sources

Spatial working memory in a disappearing object task is impaired in female but not male dogs with chronic osteoarthritis

Animal Cognition
Chronic pain in humans is associated with impaired working memory but it is not known whether this is the case in long-lived companion animals, such as dogs, who are especially vulnerable to developing age-related chronic pain conditions.
Melissa Smith, Joanna C. Murrell, Michael Mendl   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source