Results 91 to 100 of about 3,265,521 (286)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Educación MédicaResumen: Introducción: las condiciones laborales de los médicos internos residentes (MIR) han demostrado tener un gran impacto en su salud y formación. Durante los últimos años se han publicado los primeros estudios analizando esta realidad. Sin embargo,
Lucía Escabias Criado +4 more
doaj +1 more source
Income, Happiness, and the Disutility of Labour [PDF]
We reexamine the claim that the effect of income on subjective well-being suffers from a systematic downward bias if one ignores that higher income is typically associated with more work effort.
Andreas Knabe, Steffen Rätzel
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Decent working time: New trends, new issues. [PDF]
Includes selected papers from the 9th International Symposium on Working Time, Paris (2004), looking at the increasing use of results-based employment relationships for managers and professionals, and the increasing fragmentation of time to more closely ...
Boulin, Jean-Yves +3 more
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
IMPACT OF LONG WORKING HOURS ON WOMEN’S SOCIOECONOMIC EMPOWERMENT
Costos y Gestión, 2020 Due to continuous and rapid technological, cultural, and economic changes in the banking sector in specific, the need of working for long hours has increased dramatically among bankers especially after the economic crisis of 2008, which put bankers ...
Sajida El Othman
doaj +2 more sources
Jornada de trabalho: o exemplo europeu
Hours of work: the European example [PDF]
Nova Economia, 2000 This paper examines the role played by the decline in average annual hours of work per person in employment over the behavior of unemployment rate in Europe since II World War.
Fernando Augusto M. de Mattos
doaj
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source