Results 71 to 80 of about 548,690 (257)
Physical activity of graduated nurses in one-and multiple-shift work
Obzornik zdravstvene nege, 2016 Introduction: Physical activity enables nurses to better control their mental and physical strain at work, which is important for ensuring quality patient treatment.
Vanja Škrbina, Joca Zurc
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Evaluating staggered working hours using a multi-agent-based Q-learning model
Transport, 2014 Staggered working hours has the potential to alleviate excessive demands on urban transport networks during the morning and afternoon peak hours and influence the travel behavior of individuals by affecting their activity schedules and reducing their ...
Min Yang +5 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Human Right for Fair Wage: sociological aspect
Vestnik Omskoj Ûridičeskoj Akademii, 2012 The article summarizes the results of sociological research devoted to the analysis of the fair wage problem. The authors analyze the dynamics of labor load and the level of wages in the economic market conditions taking as an example the Omsk ...
Ponomareva T. M., Kalyuga E. A.
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Educación MédicaResumen: Introducción: las condiciones laborales de los médicos internos residentes (MIR) han demostrado tener un gran impacto en su salud y formación. Durante los últimos años se han publicado los primeros estudios analizando esta realidad. Sin embargo,
Lucía Escabias Criado +4 more
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