Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Mismatches between actual and preferred work time: empirical evidence of hours constraints in 21 countries [PDF]
This paper analyzes the discrepancy between actual and desired working hours in a multinational setting. Using the latest data of the International Social Survey Program (ISSP) with a focus on work orientations hours constraints in 21 heterogeneous ...
Otterbach, Steffen
core
European Working Time Directive and doctors' health: a systematic review of the available epidemiological evidence [PDF]
, 2014 Objective: To summarise the available scientific evidence on the health effects of exposure to working beyond the limit number of hours established by the European Working Time Directive (EWTD) on physicians. Design: A systematic literature search was
Ayas +49 more
core +2 more sources
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
WP RR 15 - Employees' preferences for more or fewer working hours: The effects of usual, contractual and standard working time, family phase and household characteristics and job satisfaction [PDF]
This study seeks explanations for working time preferences, using cross-sectional multinomial logits for the 2001/2002 Wage Indicator dataset (N=21,727). As expected, the preferences are predominately influenced by working hours’ characteristics, showing
Kea Tijdens
core
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Availability and accessibility to latrine and handwashing facilities during working hours among “boda-boda” drivers in Mwanza city [PDF]
, 2023 Namanya Basinda +9 more
openalex +1 more source
WP 31 - How Many Hours Do You Usually Work: an analysis of the working hours questions in 26 large-scale surveys in 6 countries and the European Union [PDF]
This paper reviews how working hours are asked in 26 large-scale surveys in 6 countries plus the European Union. Four dimensions of working time were investigated, notably number of working hours, timing of work, predictability and control over hours ...
Dragstra, A.E., Kea Tijdens
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
WP 5 - Employers' and employees' preferences for working time reduction and working time differentiation [PDF]
Working time reduction is high on the political agenda, but preferences and practices have not been studied extensively. Using large-scale survey data of 17,308 employees in Dutch banks after the introduction of the 36-hours working week by the end of ...
Kea Tijdens
core