Results 51 to 60 of about 21,974 (169)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Menopause in working life

Scandinavian Journal of Work, Environment & Health
An increasing proportion of the working-age population in Western countries consists of middle-aged or older women. Among EU countries in 2024, the employment rate of women aged 55–64 was 59%.
Johanna Kausto
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Educational differences in duration of working life and loss of paid employment: working life expectancy in The Netherlands

Scandinavian Journal of Work, Environment & Health, 2020
OBJECTIVES: This study aims to provide insight into educational differences in duration of working life by working life expectancy (WLE) and working years lost (WYL) through disability benefits and other non-employment states in the Netherlands. METHODS:
Suzan JW Robroek, Daan Nieboer, Bengt Järvholm, Alex Burdorf   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Long working hours and depressive symptoms: systematic review and meta-analysis of published studies and unpublished individual participant data

Scandinavian Journal of Work, Environment & Health, 2018
OBJECTIVES: This systematic review and meta-analysis combined published study-level data and unpublished individual-participant data with the aim of quantifying the relation between long working hours and the onset of depressive symptoms.
Marianna Virtanen, Markus Jokela, Ida EH Madsen, Linda L Magnusson Hanson, Tea Lallukka, Solja T Nyberg, Lars Alfredsson, G David Batty, Jakob Bue Bjorner, Marianne Borritz, Hermann Burr, Nico Dragano, Raimund Erbel, Jane E Ferrie, Katriina Heikkilä, Anders Knutsson, Markku Koskenvuo, Eero Lahelma, Martin Lindhardt Nielsen, Tuula Oksanen, Jan H Pejtersen, Jaana Pentti, Ossi Rahkonen, Reiner Rugulies, Paula Salo, Jürgen Schupp, Martin J Shipley, Johannes Siegrist, Archana Singh-Manoux, Sakari B Suominen, Töres Theorell, Jussi Vahtera, Gert G Wagner, Jian Li Wang, Vasoontara Yiengprugsawan, Hugo Westerlund, Mika Kivimäki   +36 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

İlk Dönem İslam Tarihinde Kadının Konumu

Artuklu Akademi, 2018
İnsanlığın başlangıcından bu yana güçlünün zayıfa tahakkümü toplumların en büyük problemi olmuştur. Cahiliye döneminde kadınlar, babalarının ve kocalarının sahip oldukları bir meta gibi algılanır ve ona göre muamele görürlerdi.
Ahmet Acarlıoğlu
doaj