Results 71 to 80 of about 11,225,660 (297)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Enhanced Campus Life Executive Summary [PDF]

open access: yes, 2013
The Enhanced Campus Life Working Group was formed by President Armstrong who identified an opportunity to create a culture for 24/7 campus life that meets the academic and social needs of the students, whether living on or off campus.
Enhanced Campus Life Working Group,
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Educated Working Women and Their Work-Life Conflict and Work-Life Balance

open access: yesPakistan Journal of Gender Studies, 2018
It is a fact that women are effectively supporting men in financial perspectives since ages but different problems such as attitude and prejudice of society members adversely affect the utilization of their talent and working abilities .The objectives of this study were to (a) find out the work life conflict and work-life balance of working women’ (b ...
Munazza Mahmood   +2 more
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Extending working life in Finland. CEPS Working Document No. 387, 22 November 2013 [PDF]

open access: yes, 2013
This report reviews national and private initiatives to allow the elderly to continue their participation in the Finnish labour market and provides an analysis of the labour market and living conditions of seniors.
von Werder, Marten   +1 more
core  

Covid-19 Pandemi Sürecinin Farklı Alanlarda Dijitalleşmeye Etkileri: Kavramsal Bir Değerlendirme

open access: yesHitit Ekonomi ve Politika Dergisi, 2021
2019 yılı Aralık ayında Çin’ in Hubei Eyaletinin Wuhan kentinde ortaya çıkan yeni solunum yolu hastalığı II. Dünya Savaşından sonra dünya genelinde yaşanan en büyük sağlık kaynaklı sosyo-ekonomik kriz olarak karşımıza çıkmaktadır.
Ece Kırlı Özen, Mehmet Marangoz
doaj  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

İlk Dönem İslam Tarihinde Kadının Konumu

open access: yesArtuklu Akademi, 2018
İnsanlığın başlangıcından bu yana güçlünün zayıfa tahakkümü toplumların en büyük problemi olmuştur. Cahiliye döneminde kadınlar, babalarının ve kocalarının sahip oldukları bir meta gibi algılanır ve ona göre muamele görürlerdi.
Ahmet Acarlıoğlu
doaj  

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