Results 61 to 70 of about 11,225,660 (297)

Increasing labor force participation in older age requires investments in work ability

Scandinavian Journal of Work, Environment & Health, 2021
For well over 100 years, life expectancy in developed societies has increased by 2.5 years per decade (1). At first, most of the increase was due to decreased death rates at younger ages, but since the 1950s, the main reason has been better survival ...
Mikko Laaksonen
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Work/Life Unbalanced

College & Research Libraries, 2020
Living in Strange Times Everyone’s personal and professional lives have changed significantly over the past month or so and it feels like real life took a vacation and never came back, leaving us with… whatever this is.
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Factors influencing the decision to extend working life or retire

Scandinavian Journal of Work, Environment & Health, 2011
OBJECTIVE: The aim of this study was to evaluate factors within nine identified areas that influence why some older workers want to (or believe they can) work until age 65 years or beyond, whereas others leave the workforce earlier.
Kerstin Nilsson, Anna Rignell Hydbom, Lars Rylander   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Health and prolonging working lives: an advisory report of the Health Council of The Netherlands

Scandinavian Journal of Work, Environment & Health, 2019
OBJECTIVE: This opinion paper summarizes the main findings and recommendations of an advisory report on health and prolonging working life, which was requested by the Dutch Minister of Social Affairs and Employment.
Kerstin G van der Mark-Reeuwijk, Rianne M Weggemans, Ute Bültmann, Alex Burdorf, Dorly JH Deeg, Goedele A Geuskens, Kène CJIM Henkens, IJmert Kant, Annet de Lange, Maarten Lindeboom, Willem van Rhenen, Allard J van der Beek   +11 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Changes in working life expectancy with disability in the Netherlands, 1992–2016

Scandinavian Journal of Work, Environment & Health, 2019
OBJECTIVES: Like other western countries, the Netherlands has abolished early retirement schemes and is currently increasing the statutory retirement age. It is likely that also older workers with disabilities will be required to work longer.
Maaike van der Noordt, Suzan van der Pas, Theo G van Tilburg, Ardo van den Hout, Dorly JH Deeg   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source