Results 151 to 160 of about 736,084 (308)
Advanced Science, EarlyView.This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin +12 more
wiley +1 more source
Lo humano en la obra de Manuel Rivas: un puente entre lo gallego y lo universal [PDF]
, 2012 [Resumo] Manuel Rivas nunca deixa de recalcar a dimensión universal da súa obra coma se quixese apropiarse da soada fórmula das Irmandades da Fala ‘Galicia, célula de universalidade’.
Vaz, Jorge
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Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Globalization Report 2018: Who Benefits Most from Globalization? Bertelsmann Policy Brief #2018/02 [PDF]
, 2018 There is growing uncertainty in industrialized countries as to whether globalization means more opportunity or more risk. Trump, Brexit and increasing populism are direct consequences of this development.
Jungbluth, Cora +3 more
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Advanced Science, EarlyView.Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He +10 more
wiley +1 more source
Stefan Zweig, Alfredo Cahn and the perfect translation [PDF]
, 2019 La obra literaria del escritor austríaco Stefan Zweig (1881- 1942) se hizo muy conocida en el mundo hispanoparlante sobre todo a partir de las traducciones del suizo Alfredo Cahn (1902-1975) afincado en la Argentina desde la década del ’20. En mi trabajo
Vazquez, María Ester
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Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations
Advanced Science, EarlyView.Phosphatidylserine acts as a lipid trigger to enhance activation of the sheddase ADAM10. By integrating fluorescence spectroscopy assays with enhanced sampling molecular dynamics simulations, this study shows that phosphatidylserine promotes ADAM10 catalytic activity along with expansion of its extracellular domains, enhancing accessibility to scaffold
Adrien Schahl +7 more
wiley +1 more source
New directions in the analysis of inequality and poverty [PDF]
, 2007 Over the last four decades, academic and wider public interest in inequality and poverty has grown substantially. In this paper we address the question: what have been the major new directions in the analysis of inequality and poverty over the last ...
Jenkins, Stephen, Micklewright, John
core +2 more sources
De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning
Advanced Science, EarlyView.Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li +23 more
wiley +1 more source
Miriše na pragmatizam: Wittgensteinova antiskeptična oružja [PDF]
, 2003 In the text the author tries to investigate Wittgenstein’s notions of action, practice and pragmatism in his book On Certainty. An attempt is made to sketch the criterion of Wittgenstein’s analysis of certainty and to define the crucial concepts such as ...
Kristijan Krkač
core +1 more source