Results 11 to 20 of about 730,768 (269)

FK506 increases susceptibility to musculoskeletal infection in a rodent model

BMC Musculoskeletal Disorders, 2022
Background Delayed fracture healing caused by soft tissue loss can be resolved by the administration of a Th1 immunosuppressant, such as FK506. Additionally, open fractures are at high risk for infection.
Stefanie M. Shiels, Preeti J. Muire, Joseph C. Wenke   +2 more
doaj   +1 more source

Stages of preadipocyte differentiation: biomarkers and pathways for extracellular structural remodeling

Hereditas, 2022
Background This study utilized bioinformatics to analyze the underlying biological mechanisms involved in adipogenic differentiation, synthesis of the extracellular matrix (ECM), and angiogenesis during preadipocyte differentiation in human Simpson ...
Zhihan Hu, Yi Liu, Zongjiang Yao, Liming Chen, Gang Wang, Xiaohui Liu, Yafei Tian, Guangtong Cao   +7 more
doaj   +1 more source

Clinical Effect of Emergency Dermabrasion Combined with Biological Dressing A on Wound Microcirculation and Preventing Sepsis in Deep Degree-II Burns

Emergency Medicine International, 2022
Objective. The aim of this study is to explore the clinical effect of emergency dermabrasion combined with biological dressing A on wound microcirculation and preventing sepsis in deep degree-II burns. Methods.
Huawei Shao, Ru Luo, Chuangang You, Qiong Li, Shulei Mao   +4 more
doaj   +1 more source

Pilot testing the new Amit Jain’s scoring system for diabetic foot ulcer in predicting the risk of amputation

Medicine Science, 2021
The aim of this study was to test the new Amit Jain’s diabetic foot ulcer scoring and determine the predictive validity of this simple scoring for amputation in diabetic foot ulcers.
Amit Kumar C Jain, Apoorva HC, Kishore Kumar G   +2 more
doaj   +1 more source

Neutralization of HMGB1 improves fracture healing and γδ T lymphocyte counts at the fracture site in a polytrauma rat model

Journal of Experimental Orthopaedics, 2022
Purpose Delayed fracture healing is a common consequence of polytrauma (PT) occurring in patients with multiple injuries. We believe that when early release of high mobility group box 1 (HMGB1) molecules from necrotic tissues exceed their normal levels ...
Preeti J. Muire, Joshua J. Avila, Alicia L. Lofgren, Joseph C. Wenke   +3 more
doaj   +1 more source

Local autologous platelet rich plasma injection combined with platelet rich fibrin filling as the main treatment for refractory wounds: A case series

Frontiers in Surgery, 2023
Refractory wounds are a major global health problem that not only affects the quality of life, but also causes significant physical, psychological and economic burdens. How to promote wound healing has become the main goal of clinicians.
Xiang Liu, Xiangjun Li, Wei Wei, Xiang Zhang, Zheng Fang, Zixiu Chen, Pingxiang Chen, Haihong Li, Haihong Li   +8 more
doaj   +1 more source

Endovascular therapy with intravascular ultrasound guidance for popliteal artery occlusion due to blunt trauma

EJVES Short Reports, 2015
Background: Historically, popliteal artery occlusion due to blunt trauma has led to high amputation rate and been thought that indication for traditional open operative repair in almost all of cases.
Makoto Utsunomiya, Yoshihiro Takami, Koichi Kusunose, Ken Hayashi, Sachiyo Osawa, Kumiko Chuman, Ryohei Matsuo, Masato Nakamura   +7 more
doaj   +1 more source

COMPLEX WOUNDS [PDF]

Clinics, 2006
Complex wound is the term used more recently to group those well-known difficult wounds, either chronic or acute, that challenge medical and nursing teams. They defy cure using conventional and simple "dressings" therapy and currently have a major socioeconomic impact.
Ferreira, Marcus Castro, Tuma Júnior, Paulo, Carvalho, Viviane Fernandes, Kamamoto, Fábio   +3 more
openaire   +4 more sources

Fracture healing in a polytrauma rat model is influenced by mtDNA:cGAS complex mediated pro‐inflammation

Journal of Experimental Orthopaedics, 2023
Purpose The mitochondrial DNA (mtDNA) activated cyclic guanosine monophosphate–adenosine monophosphate synthase—stimulator of interferon genes (cGAS‐STING) signaling pathway is a key player in mediating immune responses in autoimmune disorders and cancer.
Preeti J. Muire, Alicia L. Lofgren, Stefanie M. Shiels, Joseph C. Wenke   +3 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source