Results 41 to 50 of about 338,449 (266)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Burn Wound Infections [PDF]

Clinical Microbiology Reviews, 2006
SUMMARYBurns are one of the most common and devastating forms of trauma. Patients with serious thermal injury require immediate specialized care in order to minimize morbidity and mortality. Significant thermal injuries induce a state of immunosuppression that predisposes burn patients to infectious complications.
Deirdre, Church, Sameer, Elsayed, Owen, Reid, Brent, Winston, Robert, Lindsay   +4 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

HUBUNGAN TINGKAT KEPATUHAN PELAKSANAAN PROTAP PERAWATAN LUKA DENGAN KEJADIAN INFEKSI LUKA POST SECTIO CAESAREA (SC) DI RUANG MAWAR I RSUD DR. MOEWARDI SURAKARTA

Jurnal Berita Ilmu Keperawatan, 2008
Backgraund: Indonesian country have the most negatif dateless accidently, special to infection of wound patient post section caesarea. At Cipto Mangunkusumo Jakarta hospital in 1990 year be present dateless infection of wound 12% is unadulterated ...
Himatusujanah Himatusujanah, Faizah Bety Rahayuningsih   +1 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

COMPARATIVE STUDY BETWEEN INTERRUPTED MATTRESS AND CONTINUOUS SUBCUTICULAR SKIN CLOSURE IN REGARDING POST-APPENDECTOMY WOUND INFECTION [PDF]

Basrah Journal of Surgery, 2016
Historically, potentially infected surgical wounds, like in acute appendicitis, were recommended to be closed by interrupted skin suturing. However, this method of skin closure can leave a marked scar at the closure site after healing of the wound.
Ahmed Abdul-Hadi Safar
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Comparison of Injury Severity Score (ISS) and New Injury Severity Score (NISS) in the Evaluation of Thoracic Trauma Patients: A Retrospective Cohort Study

Emergency Medicine International
Objective. To explore the value of the injury severity score (ISS) and the new injury severity score (NISS) for evaluating injuries and predicting complications (pneumonia and respiratory failure) and poor prognoses (in-hospital tracheal intubation ...
He Jin, Yuanyuan Zhang, Qi Zhang, Lijuan Ouyang, Xueyao Li, Yiyan Zhang, Baosheng Yang, Junfeng Sun, Chaohui Wei, Guimei Yang, Li Guan, Shilan Luo, Junyu Zhu, Huaping Liang   +13 more
doaj   +1 more source

Interpretation of wound infection risk assessment, identification and diagnosis in "Wound infection in clinical practice：principles of best practice（2022 edition）" by the International Wound Infection Institute

Huli yanjiu, 2023
This paper interpreted the contents of wound infection risk assessment，infection identification and diagnosis in "Wound infection in clinical practice：principles of best practice（2022 edition）" by the International Wound Infection Institute，in order to ...
ZHENG Hongling, JIANG Lu, SU Qiong
doaj