Results 51 to 60 of about 2,574,127 (301)

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Bacterial stimulation triggers IRF7-mediated IFN-λ production in hepatocytes to attenuate sepsis

Cellular and Molecular Life Sciences
Interferon lambda (IFN-λ) is produced early by hematopoietic or epithelial cells and acts as a primary mediator of frontline antiviral defense without inducing inflammatory responses.
Wei Ma, Junjie Shu, Wanqi Tang, Haoru Liu, Hao Zhang, Xue Yang, Qiangguo Gao, Huaping Liang, Xia Yang   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Neutrophilic granule protein promotes lipopolysaccharide-induced iNOS/NO expression via JAK2/STAT1 signaling pathway and augments bacteria clearance of macrophages

Cellular and Molecular Life Sciences
Neutrophilic granule protein (NGP) was identified as a granular protein in neutrophils, but its function in macrophages has not been fully understood. In our prior investigation, NGP was observed to be significantly upregulated in macrophages following ...
Lixing Tian, Shuangqin Yin, Jing Wang, Hongyan Xiao, Tianyin Kuang, Li Luo, Shengxiang Ao, Jing Zhou, Xue Yang, Lin Qiao, Yidong Yang, He Jin, Mu Yuan, Yongming Li, Xiangwei Hou, Xiang Xu, Huaping Liang, Junyu Zhu   +17 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Vacuum-assisted closure (VAC®) systems and microbiological isolation of infected wounds

World Journal of Emergency Surgery, 2018
Background Negative pressure wound therapy is now largely used to treat infected wounds. The prevention and reduction of healthcare-associated infections is a high priority for any Department of Health and great efforts are spent to improve infection ...
Valerio Cozza, Gilda Pepe, Marco Cintoni, Flavio De Maio, Giuseppe Tropeano, Sabina Magalini, Gabriele Sganga, Giovanni Delogu, Daniele Gui   +8 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Identification of risk factors by systematic review and development of risk-adjusted models for surgical site infection [PDF]

, 2011
Background: Surgical site infections (SSIs) are complications of surgery that cause significant postoperative morbidity. SSI has been proposed as a potential indicator of the quality of care in the context of clinical governance and monitoring of the ...
Wilson, AP, Pearson, A. (Andrew), ZH Krukowski, Bruce, J, Krukowski, Zygmunt H., Gibbons, C., Pearson, A, Lamping, Donna Louise, Reeves, BC, AP Wilson, DL Lamping, J Wilson, Krukowski, ZH, Lamping, DL, J Carpenter, Krukowki, ZH, J Bruce, Carpenter, J., Gibbons, C, A Pearson, Wilson, J, Wilson, A. P. (A. Peter), BC Reeves, Reeves, B. C., Wilson, Jennie, RGN, C Gibbons, Bruce, J. (Julie), Carpenter, J   +27 more
core   +1 more source

Trichophyton as a Rare Cause of Postoperative Wound Infection Resistant to Standard Empiric Antimicrobial Therapy

Case Reports in Pediatrics, 2018
Fungal infections are rare causes of acute surgical wound infections, but Candida is not an infrequent etiology in chronic wound infections. Trichophyton species is a common cause of tinea capitis but has not been reported as a cause of neurosurgical ...
Sheema Gaffar, John K. Birknes, Kenji M. Cunnion   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source