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Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu+11 more
wiley +1 more source
Development of a deep learning-based tool to assist wound classification [PDF]
This paper presents a deep learning-based wound classification tool that can assist medical personnel in non-wound care specialization to classify five key wound conditions, namely deep wound, infected wound, arterial wound, venous wound, and pressure wound, given color images captured using readily available cameras. The accuracy of the classification
arxiv
The Monitoring of Bark Integrity from Phytosanitary Point of View on Plum Trees Plantations in Reghin Area [PDF]
A special importance in long developing of plum is the health of the primary elements of stem and main branches structure. The bark injuries (wounds) may be of mechanical or pathological origin or a combination between these.
BEREKMERI, Valentin, PUIA, Carmen
core +2 more sources
Heart Injury with Projectile Lodged Inside the Heart
Penetrating heart injuries present high mortality rates. Increasing rates of urban violence have contributed to a significant rise in the number of heart injuries by firearm projectiles. Such injuries are associated with the highest mortality rates among
Marco Antônio Volpe+5 more
doaj +1 more source
Fatal injury by air gun: a case report
Background The popularity of air weapons is increasing. They are often viewed as toys, rather than potentially lethal weapons. Regulations on purchase and ownership of air weapons differ from country to country.
Boris Dumenčić+3 more
doaj +1 more source
Comments on "Ballistics: a primer for the surgeon" [PDF]
In response to a published assertion to the contrary, this paper briefly reviews many studies that document remote wounding effects of ballistic pressure waves including experiments in pigs and dogs that find brain injury resulting from animal models shot in the thigh and case studies in humans that document both remote brain and spinal cord injuries ...
arxiv
WSES classification and guidelines for liver trauma [PDF]
The severity of liver injuries has been universally classified according to the American Association for the Surgery of Trauma (AAST) grading scale. In determining the optimal treatment strategy, however, the haemodynamic status and associated injuries ...
Abu-Zidan, Fikri M.+18 more
core +2 more sources
The Use of Biologic Scaffolds in the Treatment of Chronic Nonhealing Wounds.
Significance: Injuries to the skin as a result of illness or injury, particularly chronic nonhealing wounds, present a major healthcare problem. Traditional wound care approaches attempt to control the underlying causes, such as infection and ischemia ...
N. Turner, S. Badylak
semanticscholar +1 more source
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya+3 more
wiley +1 more source
OBJETIVO: avaliar os aspectos epidemiológicos e fatores prognósticos associados a uma série de pacientes vítimas de traumatismo cranioencefálico por projétil de arma de fogo (PAF). MÉTODOS: Foram revisados os prontuários de 181 pacientes da Disciplina de
Rodrigo Becco de Souza+4 more
doaj +1 more source