Results 41 to 50 of about 76,979 (255)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Heart Injury with Projectile Lodged Inside the Heart

Brazilian Journal of Cardiovascular Surgery
Penetrating heart injuries present high mortality rates. Increasing rates of urban violence have contributed to a significant rise in the number of heart injuries by firearm projectiles. Such injuries are associated with the highest mortality rates among
Marco Antônio Volpe, Jorge Edwin Morocho Paredes, Luciana Costacurta Redigolo, Isaac Samuel Moscoso Sanchez, Fernando Lanichek, Luiza Zita D'Albuquerque Silveira   +5 more
doaj   +1 more source

Bacteriology of War Wounds at the Time of Injury [PDF]

Military Medicine, 2006
Bacterial contamination of war wounds occurs either at the time of injury or during the course of therapy. Characterization of the bacteria recovered at the time of initial trauma could influence the selection of empiric antimicrobial agents used to prevent infection. In the spring of 2004, U.S.
Clinton K, Murray, Stuart A, Roop, Duane R, Hospenthal, David P, Dooley, Kimberly, Wenner, John, Hammock, Neil, Taufen, Emmett, Gourdine   +7 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Traumatismo cranioencefálico por projétil de arma de fogo: experiência de 16 anos do serviço de neurocirurgia da Santa Casa de São Paulo

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: avaliar os aspectos epidemiológicos e fatores prognósticos associados a uma série de pacientes vítimas de traumatismo cranioencefálico por projétil de arma de fogo (PAF). MÉTODOS: Foram revisados os prontuários de 181 pacientes da Disciplina de
Rodrigo Becco de Souza, Alexandre Bossi Todeschini, José Carlos Esteves Veiga, Nelson Saade, Guilherme Brasileiro de Aguiar   +4 more
doaj   +1 more source

Acute Acalculous Cholecystitis in Severe Trauma Patients: A Single Center Experience [PDF]

Journal of Acute Care Surgery, 2015
Purpose: Early diagnosis and prompt treatment of acute acalculous cholecystitis is important, because it is associated with high mortality. In major trauma patients, besides the direct damage the trauma itself causes, many complications can occur due to ...
Jong Beom Kim, Yun Su Mun, Oh Sang Kwon, Min Koo Lee, Joo Seung Park, Je Ho Jang   +5 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

USE OF SPATIOTEMPORAL GAIT PARAMETERS TO DETERMINE RETURN TO SPORTS AFTER ACL RECONSTRUCTION [PDF]

Acta Ortopédica Brasileira, 2016
Objective : To compare gait spatiotemporal parameters of healthy and ACL reconstructed subjects in order to classify the status of gait normality. Methods : Fourteen healthy subjects and eight patients submitted to ACL reconstruction walked along a ...
GUSTAVO LEPORACE, LEONARDO METSAVAHT, GABRIEL ZEITOUNE, THIAGO MARINHO, TAINÁ OLIVEIRA, GLAUBER RIBEIRO PEREIRA, LISZT PALMEIRA DE OLIVEIRA, LUIZ ALBERTO BATISTA   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Prophylactic Antibiotic Therapy in Contaminated Traumatic Wounds: Two Days versus Five Days Treatment

BioImpacts, 2012
Introduction: Emergency department manages several kinds of wounds including simple, non-bite traumatic wounds and lacerations. Prophylactic antibiotic therapy is one of prescribed treatment in these conditions.
Barzin Bagheri-Behzad, Dorsa Divsalar, Shervin Farahmand, Mohammad-Reza Yasinzadeh, Ehsan Modirian, Hamed-Basir Ghafouri   +5 more
doaj   +1 more source