Results 41 to 50 of about 89,517 (245)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A review of the Groote Schuur hospital experience of low-velocity non-missile penetrating orbital and transorbital stab wounds [PDF]

, 2004
Includes bibliographical references.The aim of this study is to perform a retrospective review of all cases of low-velocity non-missile penetrating orbital trauma with intracranial complications presenting at Groote Schuur Hospital over the 5 year period
Welman, Chris
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Invisible wounds of war : summary and recommendations for addressing psychological and cognitive injuries /

, 2008
Since October 2001, approximately 1.64 million U.S. troops have been deployed for Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) in Afghanistan and Iraq.
California Community Foundation., Center for Military Health Policy Research., Rand Corporation., Tanielian, Terri L.   +3 more
core   +1 more source

Profile of thoracic trauma victims submitted to chest drainage

Revista do Colégio Brasileiro de Cirurgiões
Objective: to describe and compare the variables involved in trauma victims undergoing thoracic drainage. Methods: we conducted a retrospective, analytical, descriptive, cross-sectional study, with medical records of patients attended at the Trauma ...
CESAR AUGUSTO BROSKA JÚNIOR, ADRIANE BARBOSA BOTELHO, ANDRÉ DE CASTRO LINHARES, MARIANA SANTOS DE-OLIVERIA, GABRIELA VERONESE, CARLOS ROBERTO NAUFEL JÚNIOR, LISLAINE CRUZ BATISTA, MARIA ANGÉLICA KURPEL DIOGO   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Civilian gunshot wounds to the genitourinary tract: incidence, anatomic distribution, associated injuries, and outcomes

, 2010
Gunshot wounds (GSW) affecting the genitourinary (GU) system in civilians are uncommon. This study describes the incidence, anatomic distribution, demographics, associated injuries, management, and outcomes after civilian GU ...
Tannast, M, Soheil Najibi, Najibi, S, Jerilyn M. Latini, Latini, JM, Moritz Tannast   +5 more
core   +1 more source

Non-operative versus operative management of penetrating kidney injuries : a prospective audit [PDF]

, 2011
To date there is little data on conservative management of penetrating renal trauma. The aim of this study was to review the management and outcome of a large patient cohort presenting with penetrating renal trauma to a tertiary referral centre in South ...
Moolman, Conray
core   +1 more source

Adherence to national trauma triage criteria in Norway: a cross-sectional study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background Norwegian hospitals employed individual trauma triage criteria until 2015 when nationwide criteria were implemented. There is a lack of empirical evidence regarding adherence to Norwegian national criteria for activation of the trauma team ...
Einar Frigstad Hoås, Waleed Mohammed Majeed, Olav Røise, Oddvar Uleberg   +3 more
doaj   +1 more source