Results 121 to 130 of about 136,469 (314)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Pedagogical Efficacy of Planned v.s unplanned focus on form Instruction in Scaffolding transitional Devices used by Iranian EFL Learners in writing Paragraphs [PDF]

open access: yesJournal of English Language Teaching and Learning, 2015
Indubitably, the efficacy of metalinguistic awareness in improving EFL learners’ grammatical knowledge and writing quality has long been an area of great interest in applied linguistics Brown (2001).
Azizzolah Dabaghi   +2 more
doaj  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Investigating perceptions of master's students on English-as-a-medium-of-instruction programmes in East Asia

open access: yes, 2013
This PhD thesis is as investigation into the positionings, voices and experiences of students who use English for their postgraduate studies in the fields of business and English language teaching, in particular relation to their writing practices ...
Baird, Robert
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Argumentation in collaboration : the impact of explicit instruction and collaborative writing on secondary school students' argumentative writing

open access: yes
This paper has investigated the importance of explicit instruction and collaborative writing on (a) argumentative writing performance and (b) self-efficacy for writing of secondary school students.
Van Keer, HildePP068010011526400000-0002-9819-4864F5422C2A-F0ED-11E1-A9DE-61C894A0A6B4   +3 more
core  

Sociocultural theory and the teaching of process writing: The scaffolding of learning in a university context

open access: yes, 2005
This paper considers how independent and interdependent learning can be fostered through a process approach to the teaching of writing. It does so by presenting the theoretical rational which underlies a university academic skills programme.
Barnard, Roger, Campbell, Lucy
core  

Classroom instruction and workplace practice: values that shape teaching and performance standards

open access: yes, 1992
Instructors in every field are faced with the ongoing challenge of determining appropriate curricula, pedagogy, and evaluation criteria, and they must justify these choices to colleagues and administrators.

core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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