Results 101 to 110 of about 136,469 (314)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Need Analysis in Developing Writing Instruction for Educational Short Story Writing based on Local Narratives

Metathesis: Journal of English Language, Literature, and Teaching
Writing instruction is one of the educational tools which is very important in writing courses, including creative writing. It can help students understand how to write a specific genre of text, as well as guide students in the writing process.
Sri Wulandari, Puri Bakthawar
doaj   +1 more source

Effects of Self-Regulatory Strategy Development on EFL Learners’ Descriptive Writing and Reflective Thinking [PDF]

Research in English Language Pedagogy, 2018
Writing is a demanding, complicated, and fundamental skill which is highly noticeable in the process of learning a foreign language. Thus, it is so important to teach English as a foreign language (EFL) learners how to write effectively in English ...
Sima Samanian, Ali Roohani
doaj  

Exploring the effect of wiki-based writing instruction on writing skills and writing self-efficacy of Chinese English-as-a-foreign language learners. [PDF]

Front Psychol, 2022
Dai J, Wang L, He Y.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Genre, academic writing and e-learning: An integrated tertiary level Taiwan-based study

, 2010
The research reported here has two main focus points: online learning and the teaching of academic writing to learners of English as an additional language.
Lin, Hsiu-Chen (Antonia)
core  

Effects of utilizing self-regulated learning-based instruction on EFL students’ academic writing skills: a mixed-method investigation

Asian-Pacific Journal of Second and Foreign Language Education
Despite the growing prevalence of Self-Regulated Learning in education, its application in writing contexts to enhance students’ academic writing skills still needs to be explored and warrants urgent attention.
Candradewi Wahyu Anggraeni, Januarius Mujiyanto, Katharina Rustipa, Widhiyanto   +3 more
doaj   +1 more source

The Effect of Self-regulated Strategy Instruction on Iranian EFL Learners' Writing Ability [PDF]

Journal of Applied Linguistics, 2016
This study explored the effect of teaching Self-Regulated Strategy on the writing accuracy and cohesion of Iranian EFL learners. In so doing, this study followed the SRS instruction model, using a transition word chart, examples, and a graphic organizer.
Tayyebeh Eivazi, Iraj Khoshnevis
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source