Results 111 to 120 of about 2,349,017 (306)
Material culture in Sixteenth Century Venice: a sample from probate inventories, 1510–1615 [PDF]
This paper presents a panel of data about material culture in early modern Venice. The data are taken from three samples of Venetian probate inventories drawn up voluntarily from Venetian widows in the years 1510–1615, at intervals of roughly fifty years.
Isabella Cecchini
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Ancient written cultures and digital technology: Biblissima(+)
, 2022 Die digitale Infrastruktur von Biblissima+ basiert auf dem Biblissima-Projekt (2012-2021), das potenziell auf alle alten Sprachen und ihre Medien ausgedehnt werden kann: Es handelt sich um ein Observatorium der alten Schriftkulturen. Biblissima+ ist eine multipolare digitale Infrastruktur, die stabile Mechanismen zur Aggregation und Anreicherung ...
openaire +1 more source
Merengue: Dominican Music and Identity
, 1997 Merengue—the quintessential Dominican dance music—has a long and complex history, both on the island and in the large immigrant community in New York City.
Austerlitz, Paul
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
, 2005 La lectura, la escritura y, en general, la cultura escrita, es fundamental para alcanzar mejores niveles de desarrollo y bienestar, tanto colectivos como individuales.
openaire +1 more source
Improving advanced learners' communication skills through paragraph reading and writing [PDF]
, 2007 Japanese learners of English have suffered from an inability to become competent communicators despite their large vocabulary and good grammar. This is mainly because their messages are not presented logically.
Miyasone, Mika
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source