Results 111 to 120 of about 2,349,231 (307)

The Assyrian Heroic Epic Of Qa īne Gabbara: A Modern Poem In The Ancient Bardic Tradition [PDF]

, 2007
This work discusses a modern Assyrian epic, Qa īne Gabbara, in both its oral and written traditions, and examines its importance in marking continuity in culture, traditions and language.
Donabed, Sargon
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Improving advanced learners' communication skills through paragraph reading and writing [PDF]

, 2007
Japanese learners of English have suffered from an inability to become competent communicators despite their large vocabulary and good grammar. This is mainly because their messages are not presented logically.
Miyasone, Mika
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Ancient written cultures and digital technology: Biblissima(+)

, 2022
Die digitale Infrastruktur von Biblissima+ basiert auf dem Biblissima-Projekt (2012-2021), das potenziell auf alle alten Sprachen und ihre Medien ausgedehnt werden kann: Es handelt sich um ein Observatorium der alten Schriftkulturen. Biblissima+ ist eine multipolare digitale Infrastruktur, die stabile Mechanismen zur Aggregation und Anreicherung ...
openaire   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Written culture in Peru

, 2005
La lectura, la escritura y, en general, la cultura escrita, es fundamental para alcanzar mejores niveles de desarrollo y bienestar, tanto colectivos como individuales.
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

De l'alphabétisation des mexicains. Les premiers rudiments et les usages de la lecture et de l'écriture à Mexico (1771-1867)

L'Atelier du CRH, 2014
Kenya Bello
doaj   +1 more source

Femininity Aspect as Reflected in Lisa See\u27s Snow Flower and the Secret Fan [PDF]

, 2018
The purpose of this study is to describe forms opression faced by Chinese women in the nineteenth century as reflected in te novel “Snow Flower and the Secret Fan” written by Lisa See, then to find out the way of the Chinese women to minimize their ...
Rakhmyta, Y. A. (Yunie)
core