Quinazoline Derivative kzl052 Suppresses Prostate Cancer by Targeting WRN Helicase to Stabilize DNA Replication Forks. [PDF]
Int J Mol SciYu J +7 more
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A polymorphic variant at the Werner helicase (WRN) gene is associated with bone density, but not spondylosis, in postmenopausal womenWerner syndrome (WS) is a rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders. The gene responsible for WS has been identified as WRN, a member of the RecQ family of helicase genes. Based on the fact that patients with WS exhibit osteoporosis and osteoarthritis, the present study was ...
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DNA repair helicases: from mechanistic understanding to therapeutic implications. [PDF]
NAR CancerMenon V, Gueble SE.
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Werner syndrome as a model of aging:the role of wrn at telomeres and the impact of telomerase [PDF]
, 2014 Esteve Garcia, Anna +1 more
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[Case report: A case of Werner syndrome with compound heterozygous mutations of WRN gene].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2011 Yoshikazu, Tamori +8 more
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Endothelial cell senescence shapes T cell activity in late-stage of chronic obstructive pulmonary disease. [PDF]
Cell Death DiscovLee CM +10 more
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Context-aware gene dependency modeling via graph attention networks for precision oncology. [PDF]
J Transl MedYu G, Gong Y, Fan B, Gao J, Fan Q.
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Targeting DNA repair mechanisms in cancer therapy: the role of small molecule DNA repair inhibitors. [PDF]
NAR CancerJeong S, Chung Y, Heo S, Myung K.
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Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation. [PDF]
Aging (Albany NY)Lautrup S +18 more
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A case of atypical Werner syndrome without WRN gene mutations
, 2009 Ji Hoon Choi +5 more
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