Results 1 to 10 of about 2,149 (84)

12 Exodeoxyribonucleases of Escherichia coli

, 1981
Publisher Summary Deoxyribonucleases (DNases) catalyze the hydrolysis of phosphodiester bonds in polydeoxyribonucleotides. They are divided into two classes—namely, (1) exonucleases and (2) endonucleases. Essentially, an endonuclease can attack a covalently closed circular strand, but an exonuclease cannot because it requires a chain terminus.
Bernard Weiss
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Exodeoxyribonuclease from rat brain specific for single‐stranded DNA [PDF]

European Journal of Biochemistry, 1983
An exodeoxynuclease with single‐stranded DNA specificity has been isolated from rat brain and purified to electrophoretic homogeneity. Approximately 1100‐fold purification with a yield of 16% has been achieved by chromatography on DNA‐agarose, hydroxyapatite and Sephadex G‐200. The enzyme has a pH optimum at 8.4, requires Mg2+ or Mn2+ as a cofactor and
V A, Ivanov, A I, Gaziev, T M, Tretyak
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Purification and characterization of a novel 5′ exodeoxyribonuclease from the yeast Saccharomyces cerevisiae [PDF]

European Journal of Biochemistry, 1991
We have isolated from yeast cells an exonuclease which preferentially attacks double‐stranded DNA from the 5′ ends producing 5′‐mononucleotides as reaction products. A second typical product is a full‐length single‐stranded DNA complement, suggesting that the enzyme hydrolyzes one DNA strand in a processive manner before it associates with another DNA ...
M, Dölberg, C P, Baur, R, Knippers
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On the fidelity of DNA replication. Lack of exodeoxyribonuclease activity and error-correcting function in avian myeloblastosis virus DNA polymerase.

Journal of Biological Chemistry, 1976
Homogeneous DNA polymerase ("reverse transcriptase") from avian myeoblastosis virus was assayed for exodeoxyribonuclease activity. The substrates were defined template-initiator complexes in which different radioactive nucleotides were present at the 3'-OH termini of the initiator.
N, Battula, L A, Loeb
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Purification, Crystallization and Preliminary X-Ray Diffraction Analysis of Exodeoxyribonuclease III from Crenarchaeon <i>Sulfolobus tokodaii</i> Strain 7

Crystal Structure Theory and Applications, 2013
Exodeoxyribonuclease III (EXOIII) acts as a 3’→5’ exonuclease and is homologous to purinic/apyrimidinic (AP) endonuclease (APE), which plays an important role in the base excision repair pathway. To structurally investigate the reaction and substrate recognition mechanisms of EXOIII, a crystallographic study of EXOIII from Sulfolobus tokodaii strain 7 ...
Shuichi Miyamoto, Chieko Naoe, Masaru Tsunoda, Kazuo T. Nakamura   +3 more
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Discordant phenotype caused by TREX1 variant in siblings with Aicardi-Goutières syndrome. [PDF]

Pediatr Rheumatol Online J
Liu R, Kretschmer S, Switala P, Attia M, Lee-Kirsch MA, Wolf C.   +5 more
europepmc   +1 more source

An Ultrasensitive Label-Free Aptasensor for Insulin Detection Assisted by Exonuclease III and 2-Aminopurine. [PDF]

Molecules
Shi D, He Y, Yan G.
europepmc   +1 more source

DNA Electrochemical Sensor Based on Exonuclease III-Assisted Cycling Signal Amplification for Ultrasensitive Detection of Genetically Modified Soybean. [PDF]

Biosensors (Basel)
Niu L, Huang S, Zhao J, Yang W, Li Z, Niu S, Yang J, Chen S, Wang Q.   +8 more
europepmc   +1 more source

Human APE2 and TREX2 Repair 3'-DNA-Peptide Cross-links Derived from Abasic Sites. [PDF]

Chem Res Toxicol
Wei X, Cepeda J, Chung JM, Lee SE, Yang K.   +4 more
europepmc   +1 more source

Fragment-Based Development of NSP14 Exonuclease Inhibitors Confounded by Batch-to-Batch Variability. [PDF]

ACS Chem Biol
Coker JA, Sun R, Polzer PM, Romigh T, Goins CM, Wang NS, Jung JU, Stauffer SR.   +7 more
europepmc   +1 more source